ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This study used single-cell RNA sequencing to analyze mouse and human thyroid tissue. It discovered two distinct subtypes of thyrocytes, termed thyroid follicular cell (TFC) 1 and TFC2. These subtypes were characterized by varying levels of metabolic activity and Notch signaling: TFC1 cells exhibit higher metabolic activity and Notch signaling compared to the more quiescent TFC2 cells.Notch signaling is a crucial pathway involved in cell f...