ISSN 1662-4009 (online)

Previous issue | Volume 21 | ESPEYB21

Yearbook of Paediatric Endocrinology 2024

3. Thyroid

Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease

ey0021.3-4 | Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease | ESPEYB21

3.4. Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease

Williams Alexander T , Chen Jing , Coley Kayesha , Batini Chiara , Izquierdo Abril , Packer Richard , Abner Erik , Kanoni Stavroula , Shepherd David J , Free Robert C , Hollox Edward J , Brunskill Nigel J , Ntalla Ioanna , Reeve Nicola , Brightling Christopher E , Venn Laura , Adams Emma , Bee Catherine , Wallace Susan E , Pareek Manish , Hansell Anna L , Esko Tonu , Research Team Estonian Biobank , Stow Daniel , Jacobs Benjamin M , van Heel David A , & Health Research Team Genes , Hennah William , Rao Balasubramanya S , Dudbridge Frank , Wain Louise V , Shrine Nick , Tobin Martin D , John Catherine

Brief Summary: This study investigated genetic factors influencing normal variation in TSH levels (range 0.4 to 4.0 mIU/L) through a large genome-wide association study (GWAS) involving 247,107 European ancestry individuals. It identified 260 independent sentinel variants, of which 158 are novel. These variants explained 22.8% of TSH variance within the adult reference interval, implicating 112 putative causal genes, 76 of which had not been previously linked to TSH regulation...

ey0021.3-5 | Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease | ESPEYB21

3.5. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Sterenborg Rosalie B T M , Steinbrenner Inga , Li Yong

Brief Summary: This genome-wide association study (GWAS) meta-analysis of 271,040 European participants investigated the genetic determinants of thyroid function, including reference range serum TSH, FT4, free and total T3, proxies for metabolism (T3/FT4 ratio), as well as dichotomized high and low TSH levels. It identified 259 independent associations for TSH, 85 for FT4, and novel associations for thyroid hormone (TH) metabolism (T3/FT4 ratio). Genetic variants explained 14....

ey0021.3-6 | Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease | ESPEYB21

3.6. Genetic determinants of thyroid function in children

Mulder Tessa A , Campbell Purdey J , Taylor Peter N , Peeters Robin P , Wilson Scott G , Medici Marco , Dayan Colin , Jaddoe Vincent V W , Walsh John P , Martin Nicholas G , Tiemeier Henning , Korevaar Tim I M

Brief Summary: This study investigated the genetic determinants of thyroid function in newborns and (pre)school children by analyzing the associations between single nucleotide polymorphisms (SNPs) previously identified in adults, and childhood TSH within the reference interval, and FT4 concentrations. It included three large population-based cohorts with data on genetic variants and thyroid function: Generation R (Netherlands), ALSPAC (UK), and BLTS (Australia), comprising 7,...

ey0021.3-7 | Thyroid Function - Genetic Determinants and Associations with Health and (Thyroid) Disease | ESPEYB21

3.7. The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Hysaj Ola , for the Thyroid Studies Collaboration et al

Brief Summary: This large systematic review and individual participant data (IPD) meta-analysis investigated the association between serum TSH and FT4 concentrations and the risk of cardiovascular disease (CVD) events (coronary heart disease, stroke, and heart failure) and all-cause mortality. It included data from 134,346 participants, with a median age of 59 years (range 18-106) and a median follow-up of 11.5 years. The results indicate a J-shaped association between FT4 lev...