ISSN 1662-4009 (online)

Previous issue | Volume 21 | ESPEYB21

Yearbook of Paediatric Endocrinology 2024

ey0021.4-9 | New Mechanisms | ESPEYB21

4.9. Reduction in pappalysin-2 levels and lower IGF-I bioavailability in female adolescents with anorexia nervosa

V Barrios , A Martin-Rivada , S Guerra-Cantera , A Campillo-Calatayud , RA Camarneiro , M Graell , JA Chowen , J Argente

Brief Summary: This study investigated the effects of anorexia nervosa (AN) on the insulin-like growth factor (IGF) axis in female adolescents. It evaluated levels of various proteins and their role in the IGF axis, including pregnancy-associated plasma protein A2 (PAPP-A2) and stanniocalcins (STC-1 and STC-2). The reduced levels of PAPP-A2 may impair IGFBP cleavage, thereby reducing IGF-I bioavailability. IGF1 plays a crucial role in regulating growth, metabolism, and bone he...

ey0021.4-10 | New Mechanisms | ESPEYB21

4.10. WIP1 is a novel specific target for growth hormone action

T Apaydin , S Zonis , C Zhou , CW Valencia , R Barrett , GJ Strous , JA Mol , V Chesnokova , S Melmed

Brief Summary: This study assessed the effect of growth hormone (GH) on WIP1 (wild-type p53-inducible phosphatase 1), a key mediator of the DNA damage response (DDR). GH suppressed DDR by inducing WIP1, which dephosphorylates and inactivates ATM (ataxia-telangiectasia mutated) kinase and its downstream effectors (such as CHK2, p53 and H2AX), leading to the accumulation of unrepaired DNA, which can potentially contribute to tumorigenesis.This elegant stud...

ey0021.4-11 | New Mechanisms | ESPEYB21

4.11. Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants

EDS Freitas , KA Kras , LR Roust , EA De Filippis , SR Kimball , M Buras , CS Katsanos

Brief Summary: This cross-sectional study explored the relationship between obesity and skeletal muscle protein synthesis, focusing on the expression of IGF-I and its mRNA splice variants. It provides insights into how obesity might impair protein synthesis and IGF-I levels, potentially contributing to the reduced muscle quality observed in obese patients.This study explored IGF-I expression in the muscles of obese patients as a potential factor contribu...

ey0021.4-12 | New Mechanisms | ESPEYB21

4.12. Metabolic surgery-induced changes of the growth hormone system relate to improved adipose tissue function

S Gancheva , S Kahl , C Herder , K Strassburger , T Sarabhai , K Pafili , J Szendroedi , M Schlensak , M Roden

Brief Summary: This longitudinal study explored the impact of metabolic surgery on the growth hormone (GH)/IGF-1 axis and its subsequent effects on adipose tissue function. The results suggest that bariatric surgery enhances GH-IGF-1 levels, which are linked to improved adipose tissue function and a reduction in inflammation markers.This study explored how metabolic surgery influences the GH system, and how these changes are related to improvements in ad...