ESPE Yearbook of Paediatric Endocrinology

In brief. This basic research study used an in vitro method to recapitulate key steps in growth plate development and endochondral bone formation, using induced pluripotent stem cells (iPSCs). This method provides original material that can be used to study growth plate and bone development, to assess the consequences of genetic variants involved in bone diseases, and to test new therapies.Commentary: In vertebrates, the longitudinal growth of l...

In brief: This basic research article provides new insights into osteocyte-transcortical vessel interactions and potentially opens up new therapeutic perspectives for bone diseases associated with vascular damage.Commentary: The bone vascular system has been shown to play a critical role in controlling bone development and wound healing and provides a microenvironment for the differentiation and maturation of haematopoietic and immune cells in bone marro...