ISSN 1662-4009 (online)

Previous issue | Volume 21 | ESPEYB21

Yearbook of Paediatric Endocrinology 2024

8. Adrenals

Mechanism of the Year

ey0021.8-1 | Mechanism of the Year | ESPEYB21

8.1. Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland

A Witt , I Mateska , A Palladini , A Sinha , M Wolk , A Harauma , N Bechmann , C Pamporaki , A Dahl , M Rothe , I Kopaliani , C Adolf , A Riester , B Wielockx , SR Bornstein , M Kroiss , M Peitzsch , T Moriguchi , M Fedorova , M Grzybek , T Chavakis , P Mirtschink , VI Alexaki

Brief Summary: This study demonstrates that FADS2 is a major regulator of steroidogenesis in the adrenal gland due to its key role in shaping the lipidomic landscape of adrenocortical cells.Comment: The corticosteroids aldosterone and cortisol are produced in the zona glomerulosa and zona fasciculata of the adrenal cortex, respectively (1, 2). Excess production of aldosterone in primary hyperaldosteronism results in resistant hypertension and cardiovascu...