ey0021.8-1 | Mechanism of the Year | ESPEYB21
A Witt
, I Mateska
, A Palladini
, A Sinha
, M Wolk
, A Harauma
, N Bechmann
, C Pamporaki
, A Dahl
, M Rothe
, I Kopaliani
, C Adolf
, A Riester
, B Wielockx
, SR Bornstein
, M Kroiss
, M Peitzsch
, T Moriguchi
, M Fedorova
, M Grzybek
, T Chavakis
, P Mirtschink
, VI Alexaki
Brief Summary: This study demonstrates that FADS2 is a major regulator of steroidogenesis in the adrenal gland due to its key role in shaping the lipidomic landscape of adrenocortical cells.Comment: The corticosteroids aldosterone and cortisol are produced in the zona glomerulosa and zona fasciculata of the adrenal cortex, respectively (1, 2). Excess production of aldosterone in primary hyperaldosteronism results in resistant hypertension and cardiovascu...