ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This single centre cross-sectional study used a self-reported questionnaire to evaluate ovarian function in 1333 female young adult childhood cancer survivors (CCS).The authors used two different indicators of primary ovarian insufficiency (POI): induced puberty, reported in 5.3% and estrogen replacement therapy (ERT) at assessment, reported in 9.3%. Induced puberty was correlated with more aggressive cancer treatments, in particular the u...

Brief Summary: This paper reviewed the toxicity of radiation therapy (RT) on ovarian, uterine and vaginal tissue in childhood cancer survivors (CCSs), using data published from 1970 to 2017. Overall, 11 studies reported data on ovarian damage, 8 on uterine volume related to treatment, and 3 on vaginal effects. Most studies did not report accurate dosimetric data and dose-volume relationships, and the confounder role of chemotherapy was not considered. In general, published dat...

Brief Summary: This cross-sectional study aimed to define if childhood cancer was related to delayed achievement of psychosocial milestones in later life.Data of 252 male childhood cancer survivors (CCS) diagnosed with haematological or solid tumours between 1964 and 2000, with 6-42 years of survival, were collected and compared with 5 matched controls for each patient. CCS moved away from their parental home as frequently as population controls but were...

Brief Summary: This retrospective cohort study included 54 pre- or peri-pubertal boys affected by hematological cancer who underwent a testicular biopsy for fertility preservation at the time of diagnosis, before any gonadotoxic treatment. The presence of cancer cells in immature testicular tissue of young boys was assessed by histology, immunohistochemistry (IHC) and PCR at the time of cryopreservation, before treatment. Contamination by cancerous cells was found in 10/28 boy...

Brief Summary: This multicenter, international, retrospective study evaluated fertility potential and gonadal function in 326 adolescent and young adult cancer survivors. Risk factors for impairment included hematopoietic stem cell transplantation (HCT) conditioning regimen (myeloablative conditioning, MAC vs reduced-intensity conditioning, RIC).The prevalence of gonadal hormone failure in females was 55.3% (defined as FSH >30 mIU/mL with an estradio...

Brief Summary: The nationwide Dutch Childhood Cancer Survivor (CCS) LATER cohort study assessed by questionnaire the reproductive outcomes and reproductive health care in 1317 male CCS and 407 male siblings. This included 491 CCS and 185 siblings who expressed a previous or current desire for children. Fewer CCS than siblings reported having biological children (65% vs. 88%). The type of conception was similar between CCSs and siblings (spontaneous conception in 90% of both gr...

Brief Summary: This narrative review summarized 75 published studies on reproductive function in survivors of childhood, adolescent, and young adult Hodgkin lymphoma (HL). 41 papers reported on 5057 female HL survivors. Most young female survivors had regular menstrual cycles. The incidence of premature ovarian failure (POI) varied between 6-34%. Biochemical evidence for impaired ovarian reserve or function was frequent (low AMH 55–59%. elevated FSH 17–100%). 51 stud...

Brief Summary: This retrospective cohort study assessed whether estimated treatment gonadotoxicity and posttreatment menstrual patterns are associated with higher infertility risk perception in a group of survivors of adolescent or young adult cancer (age 15-39 years).Participants reported their menstrual pattern and infertility risk perception and were categorized as increased risk (feeling less fertile or unable to become pregnant) or no increased risk...

Brief Summary: This retrospective cohort study analysed risk ratios for preterm birth (<37 completed weeks), very preterm birth (<34 completed weeks), low birth weight (<2500 g), and small for gestational age (SGA, <10th percentile of weight for gestational age) in a large group of women diagnosed with adolescent and young adult (AYA, age 15-39 years) breast cancer, thyroid cancer, gynaecologic cancers, lymphoma, or melanoma.1648 post-can...