ESPEYB21 9. Oncology and Chronic Disease Fertility Issues (9 abstracts)
9.6. Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer: a DCCSS-LATER study
Claessens JJM , Penson A , Bronkhorst EM , Kremer LCM , van Broeder 7 E , van der Heiden-van der Loo M , Tissing WJE , van der Pal HJH , Blijlevens NMA , van den Heuvel-Eibrink MM , Versluys AB , Bresters D , Ronckers CM , Walraven I , Beerendonk CCM , Loonen JJ & Dutch later study group.
joyce.claessens@radboudumc.nl Cancer. 2024 Mar 15;130(6):995-1004. doi: 10.1002/cncr.35119. PMID: 38055238
Brief Summary: The nationwide Dutch Childhood Cancer Survivor (CCS) LATER cohort study assessed by questionnaire the reproductive outcomes and reproductive health care in 1317 male CCS and 407 male siblings. This included 491 CCS and 185 siblings who expressed a previous or current desire for children. Fewer CCS than siblings reported having biological children (65% vs. 88%). The type of conception was similar between CCSs and siblings (spontaneous conception in 90% of both groups). More CCS than siblings had consulted a reproductive specialist for infertility (34% vs. 12%). But fewer CCSs underwent assisted reproductive techniques (ART) (41% vs. 77%), and even when received, ART had a lower success rate (to father a child) (49% vs. 94%). Surgical sperm retrieval procedures were performed in only 10 CCS, but none of their partners conceived.
Gonadal failure is the most common late endocrine effect of cancer treatment. Previous studies reported that only few CCS sired a pregnancy (15%–30%). The current study focused only on men who wanted children, which could explain the overall better success rate (65%) than previously. Male CCS were almost three times more likely to consult a reproductive specialist for difficulty conceiving compared to siblings, but the use of ART following consultation was less frequent in CCS than in their healthy siblings.
The study provided no insight into details concerning ART that could clarify the potential mechanisms behind the observed difference. Fertility assessment predicting a good fertility potential has been hypothesized, but an additional reason for the lower use of ART might have been the finding of azoospermia on semen analysis. Previous studies on testicular sperm extraction (TESE) reported sperm retrieval rates of 36% in cancer survivors and live birth rates of 42% to 53% obtained with ICSI after successful TESE. Data are needed on the success rate of TESE in CCS with azoospermia and factors associated with successful sperm retrieval to inform the value of this technique.
Reference: 1. Hsiao W, Stahl PJ, Osterberg EC, Nejat E, Palermo GD, Rosenwaks Z, Schlegel PN. Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. J Clin Oncol. 2011 Apr 20;29(12):1607-11. doi: 10.1200/JCO.2010.33.7808. Epub 2011 Mar 14. PMID: 21402606.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more