ISSN 1662-4009 (online)

Previous issue | Volume 21 | ESPEYB21

Yearbook of Paediatric Endocrinology 2024

9. Oncology and Chronic Disease

Thyroid Issues in Cancer Survivors

ey0021.9-10 | Thyroid Issues in Cancer Survivors | ESPEYB21

9.10. Primary hypothyroidism in childhood cancer survivors treated with radiation therapy: a PENTEC comprehensive review

MT Milano , JA Vargo , ED Yorke , CM Ronckers , LC Kremer , SMJ Chafe , HM van Santen , LB Marks , SM Bentzen , LS Constine , IR Vogelius

Brief Summary: This review analysed 15 original studies reporting the effects of radiation therapy (RT) on thyroid gland in childhood cancer survivors (CCS). A relationship between RT dose to the thyroid gland and risk of hypothyroidism could be extrapolated from 8/15 studies. Risk of compensated hypothyroidism increased with RT dose to the thyroid: it was 12%, 25% and 44% at 10, 20 and 30 Gy, respectively. Similarly, the risk of overt hypothyroidism was 4%, 7% and 13% at 10, ...

ey0021.9-11 | Thyroid Issues in Cancer Survivors | ESPEYB21

9.11. Thyroid ultrasound screening in childhood cancer survivors following radiotherapy

JA Baran , S Halada , AJ Bauer , Y Li , A Isaza , T Patel , L Sisko , JP Ginsberg , K Kazahaya , NS Adzick , S Mostoufi-Moab

Brief Summary: This retrospective study assessed the outcome of thyroid ultrasound (US) surveillance in childhood cancer survivors (CCS) exposed to radiotherapy (RT). 306 CCS were monitored with thyroid US. Patients received TBI (45%) and/or RT to craniospinal (44%), chest (11%), and neck regions (6%). Thyroid US surveillance was started at a median interval of 9.1 years after RT; 150 patients (49%) had thyroid nodule(s); 44 patients underwent surgery, and 28 had a final diagn...

ey0021.9-12 | Thyroid Issues in Cancer Survivors | ESPEYB21

9.12. Risk of second primary thyroid cancer in cancer survivors

Y Yuan , P Sun , H Xiao , L Li , J Li , X Ai

Brief Summary: This retrospective study evaluated the risk and clinicopathological features of second primary thyroid cancer (SPTC) in cancer survivors. The Surveillance, Epidemiology, and End Results (SEER) Program collected cancer incidence and mortality data from 8 population-based registries. They identified 7066 patients with SPTC and 83,113 patients with primary thyroid cancer (TC). The standardized incidence ratio (SIR) of SPTC in cancer survivors was higher than in the...