ESPE Yearbook of Paediatric Endocrinology

Int J Obes (Lond). 2020 Oct;44(10):2011–2022. 10.1038/s41366-020-0644-1. https://pubmed.ncbi.nlm.nih.gov/32713944/Schur et al. addressed the question, whether responsiveness to visual food cues in functional magnetic resonance imaging (fMRI) is related to the treatment success of a 6-month Family-based Behavioral Treatment (...

Christian.roth@deattlechildrens.org J Clin Endocrinol Metab. 2022; doi: 10.1210/clinem/dgac299. https://pubmed.ncbi.nlm.nih.gov/35544121/Brief Summary: In this intervention study, the effect of a 24-week family-based behavioral obesity intervention on brain activation, measured by v...

Brief summary: Roth et al. studied the relationship between obesity outcomes and meal-induced changes in neural activation to high- versus low-calorie food cues before and after 24-week family-based behavioral treatment (FBT) in n=28 children (9–11 years) with obesity and in n=17 children of healthy weight without intervention (9–11 years). Among children with obesity who underwent FBT, unfavorable changes were observed in peripheral hormon...

J Pediatr. 2021 Dec 20:S0022-3476(21)01236-1. doi: 10.1016/j.jpeds.2021.12.030. PMID: 34942182https://www.sciencedirect.com/science/article/pii/S0022347621012361Brief Summary: This study evaluates the efficacy and safety of GnRH analogue treatment with Central Precocious Puberty (CPP) for patients under 2 y...

To read the full abstract: Nat Commun. 2018 Feb 21;9(1):588Media-related activities take up roughly 6–9 hours of the average American youth’s day. Likely, this plays an important role in adolescent development. Recently, cognitive neuroscience studies have used structural and functional magnetic resonance imaging (fMRI) to examine brain changes over the course of adolescence. Cog...

J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3660–71. 10.1210/clinem/dgaa479. https://academic.oup.com/jcem/article/105/10/e3660/5879679In brief: This phase 3 multi-centre, open-label, single-arm study explores the efficacy, pharmacokinetics and safety of 6-monthly 45-mg subcutaneous leuprolide acetate in 59 pati...

To read the full abstract: N Engl J Med 2018;378:1987-1998FGF-23 is the primary regulator of phosphate homeostasis and acts by inhibiting phosphate reabsorption in the kidney (1). Loss-of-function mutations in the gene encoding phosphate-regulating endopeptidase homolog X-linked (PHEX) results in excess circulating FGF-23, which impairs renal phosphate reabsorption causing hypophosphatemia...

To read the full abstract: Nat Metab 2019;1:1202–1208.Metformin has become a mainstay in the treatment of T2DM in over six decades of clinical use and is today one of the world’s most commonly prescribed drugs. Anti-diabetic properties of metformin rely on an inhibition of hepatic glucose output through AMPK-dependent, but also AMPK-independent effects (reviewed in (1)). Neverthel...

J Appl Toxicol. 2021 Apr;41(4):572–586. doi: 10.1002/jat.4066. PMID: 329695In this study, pregnant dams were exposed to different types of organophosphate flame retardants (OPFRs) at a sensitive development period (from gestation to lactation). The offspring were fed either a high or a low-fat diet for 17 weeks and then underwent a battery of metabolic assessments. OPFR exposure did not alte...

Diabetologia 2019 Feb;62(2):249–258. doi: 10.1007/s00125-018-4758-0.This is the first population-based study to examine the relative contribution of maternal diabetes, excess birthweight and breast-feeding on the risk of being overweight and obese in childhood.Being large for gestational at birth is a potentially modifiable factor and this study highlights the...