ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Endocrinology 2019;160:2165–2179This paper characterize viral insulin/IGF-1–like peptides (VILPs), which the authors identified in four members of the Iridoviridae family - viruses with double-stranded DNA genomes, which are found in amphibians, fish, and invertebrates. VILPs can bind to human insulin and IGF-1 receptors and stimulate classic post-receptor signaling pathways. They can stimulate glucose uptake...

To read the full abstract: Diabetes Care 2018;41:1089-1096These findings show that a 1-SD increase in childhood BMI was associated with a 47–83% increased relative risk of T2DM and a 28% increased relative risk of CAD in adult life, yet childhood BMI was not associated with adult chronic kidney disease. This is the first study to examine the causal relationship between childhood BMI and cardio-...

Front Endocrinol 2021; 12:624507. doi: 10.3389/fendo.2021.624507– This systematic review identified 41 Chinese studies totalling 7,853,756 newborns who underwent neonatal CAH screening– The overall incidence of CAH in China was 1/23,024 (95% CI, 1/25,757 to 1/20,815)– Among the CAH patients, the Male:Female ratio was 1.92:1, and 76% presented with salt wasting<p class=...

Eur J Endocrinol. 2021 May 24;185(1):77-85. doi: 10.1530/EJE-20-1332. PMID: 33914700.Brief Summary: This case control study assessed beta-cell function and glucose metabolism in large for gestational age (LGA) infants in relation to their weight and growth parameters at 2 years of age. In LGA infants, changes in growth parameters were associated with changes in insulin resistance and beta-cell dy...

Christian.roth@deattlechildrens.org J Clin Endocrinol Metab. 2022; doi: 10.1210/clinem/dgac299. https://pubmed.ncbi.nlm.nih.gov/35544121/Brief Summary: In this intervention study, the effect of a 24-week family-based behavioral obesity intervention on brain activation, measured by v...

To read the full abstract: Pediatr Blood Cancer. 2019 Oct;66(10):e27927. yeh@mmh.org.twThis monocentric observational study analysed the efficacy of denosumab in addition to calcium and vitamin D supplementation on bone mineral density (BMD) in 113 young childhood cancer survivors (CCS) with initial BMD Z -score < –1.5.Low BMD is common in CCS, due to cancer-related fac...

To read the full abstract: Cancer. 2018;124:2220-2227The Brief Coping Orientation to Problem Experience (brief COPE) questionnaire was designed to explore the coping strategies used by individuals in response to stress. It has been used to research various populations with chronic health conditions (1). ‘Betweenness centrality’ is a measure of centrality in a graph based on shortest path...

To read the full abstract: Diabetes Care. 2018;41:1227-1234Health care is being delivered by organizations that can be regarded as representing ´health industries´. Health care providers work within complex financial constraints and frequently within for profit settings and tight financial frameworks. Hence, health provision is more and more driven by cost-effectiveness and the willingness ...

Brief summary: Roth et al. studied the relationship between obesity outcomes and meal-induced changes in neural activation to high- versus low-calorie food cues before and after 24-week family-based behavioral treatment (FBT) in n=28 children (9–11 years) with obesity and in n=17 children of healthy weight without intervention (9–11 years). Among children with obesity who underwent FBT, unfavorable changes were observed in peripheral hormon...

Brief Summary: This experimental study quantified the physiological contribution of pancreatic δ-cells to the glycemic set point. It used 3 orthogonal mouse models to remove somatostatin (SST) signalling within the pancreas or transplanted islets. Ablation of δ-cells or SST decreased the glycemic set point, and the glucose threshold for insulin response from β-cells, leading to increased insulin secretion to the same glucose challenge.The ...