ESPE Yearbook of Paediatric Endocrinology

Brief summary: This study assessed the relation between the metabolic syndrome (MetS) and sensorineural hearing loss in children with obesity. Children with MetS were shown to have subclinical hearing loss compared to those without MetS.Comment: Associations between obesity and hearing loss have been reported in several adult studies.1 However, similar studies in adolescents have yielded conflicting results. The present study aimed to address ...

To read the full abstract: Lancet 2020;395(10236):1544–45.This study tested the association between age and BMI using data from patients (n =265) with COVID-19 infection treated at the intensive care units at 6 US University Hospitals. Results show a significant inverse correlation between age and BMI in this sample. Interestingly, adolescents and young adults were more likely...

Abstract: N Engl J Med. 2018 Jun 28;378(26):2543–2544.In brief: This article reviews important developments and major advances in characterizing autoimmunity in patients with autoimmune polyendocrine syndromes, such as the identification of new autoantibody targets associated with distinct diseases and their manifestations. The authors also provide an up to date review...

Endocr J. 2021 Apr 3. doi: 10.1507/endocrj.EJ21-0050. PMID: 33814485.Mizue Fujii and colleagues retrospectively evaluated the pituitary function in 67 and 111 adult patients with Rathke’s cleft cyst (RCC) and non-functioning pituitary adenoma (NFA), respectively. The study population represented consecutive patients encountered in their institute. They found that RCCs were smaller t...

In Brief: The population-based Stockholm-Gotland Perinatal Cohort study analysed electronic medical records on 15 760 pregnancies with obesity, followed up for a median of 7.9 years. In pregnancies with class 1 or 2 obesity, low gestational weight gain (GWG, mean 0 kg at 40 weeks) did not increase risk of the adverse composite outcome (class 1: adjusted RR 0.97 [95% CI 0.89–1.06]; class 2: 0.96 [0.86–1.08]). In pregnancies with class 3 obesity, low GWG (mean 0 kg at ...

Brief Summary: This multicentre retrospective cross-sectional study provides critical insights into the epidemiology, clinical presentation, and neurodevelopmental outcomes of central congenital hypothyroidism (CCH).CCH is a rare disorder that occurs due to insufficient hypothalamic-pituitary stimulation of the thyroid, characterized by low total T4 (TT4) with either low, normal or slightly elevated TSH. Most newborn screening (NBS) programs for CH are p...

Sudan J Paediatr 2021;21:53–60. doi: 10.24911/SJP.106-1588448825– This paper describes the characteristics of 156 children and adolescents with hypopituitarism from 2 hospitals in Sudan– Congenital causes (86.5%) were more prevalent than acquired causes (13.5%)– Consanguinity was found in 77.8% of patients overall and 91% of patients with congenital aetiologies. The...

JAMA Netw Open. 2021;4(3):e214117. https://bit.ly/3zopFZ4This prospective observational cohort study (n=4638) measured vitamin D level in the year before undergoing COVID-19 testing. The risk of a positive COVID-19 test in Black, but not White, individuals was 2.64-fold higher if vitamin D level was 30–40 ng/ml compared to > 40 ng/ml.Vitamin D may improve immune functi...

Thyroid. 2022 Feb;32(2):196-205. doi: 10.1089/thy.2021.0304. Epub 2021 Dec 31. PMID: 34641706Brief Summary: This phase 1, double-blind, randomized, single-dose, placebo-controlled, crossover study compared pharmacokinetics, pharmacodynamics, incidence of adverse events, and sleep pattern between the routinely used L-triiodothyronine (LT3) and a newly developed metal-coordinated form of LT3 (pol...

The Journal of Clinical Endocrinology & Metabolism, 2021, Vol. 106, No. 9, e3634–e3643PMID: 33950234Brief Summary: This trial explored the effects of rhGH treatment in patients with Prader-Willi syndrome (PWS) on respiratory and sleep parameters. The trial was randomized and placebo-controlled for 1 year, followed by a 2-year, open-phase GH treatment period. Polysomnography performed every 6 months revealed no adverse effects of rhGH tr...