ESPE Yearbook of Paediatric Endocrinology

J Clin Endocrinol Metab. 2022 Jan 1;107(1):e246-e253. doi: 10.1210/clinem/dgab601. PMID: 34407200.Brief Summary: This retrospective single center study in neonates with hyperinsulinaemic hypoglycaemia examined the utility of real-time continuous glucose monitoring (CGM). CGM is best placed as an adjunct to routine intermittent blood glucose monitoring, providing information on glucose trends d...

Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD013309. doi: 10.1002/14651858.CD013309.pub3. PMID: 34931697.Brief Summary: This systematic review assessed the evidence for continuous glucose monitoring (CGM) to prevent morbidity and mortality in preterm infants. There was uncertainty about the safety of CGM and the available management algorithms, and many morbidities remain unreporte...

Diabetes Care. 2021 Nov;44(11):2536-2541. doi: 10.2337/dc21-0327. PMID: 34475030.Brief Summary: This retrospective case control study investigated changes in the metabolic profile in newborn screening of infants born to mothers who had been treated with metformin. Treatment with metformin during pregnancy was associated with subtle changes in metabolites in the newborn screening.<p class="abste...

J Clin Endocrinol Metab. 2021 Sep 27;106(10):e3990-e4006. doi: 10.1210/clinem/dgab412. PMID: 34105732Brief Summary: This observational monocenter study analyzed cognitive scores of children with permanent (n=28, with athyreosis, ectopy or hypoplasia) vs. transient (n=11, with thyroid gland in situ) congenital hypothyroidism (CH) compared to healthy children (‘controls&#1...

Endocrinology 163, bqac005. (2022).Abstract: https://pubmed-ncbi-nlm-nih-gov/35041746/In Brief: C-type natriuretic peptide (CNP) is known to stimulate enchondral bone formation, but the distinct cellular pathways and cellular targets are unclear. This study used in vivo and in vitro biosensor systems to identify cGMP-induced activation of PKA as a major effect of CNP with growth promoting e...

J Clin Endocrinol Metab. 2022; 107(1): 150-166. PMID: 34487152https://pubmed.ncbi.nlm.nih.gov/34487152/Brief Summary: This translational study determined the persistent visceral adipose tissue (VAT) transcriptomic alterations and epigenetic fingerprints induced by chronic hypercortisolism in patients with Cushing’s syndrome (CS) and in a reversible CS mouse model....

p.froguel@imperial.ac.uk Diabetes 2022;71:694–705https://doi.org/10.2337/db21-0373Brief Summary: In this observational cross-sectional study in 128 randomly selected young obese adults (BMI 37.2±0.3 kg/m2; age 18.4±0.3 years) from the Severe Obesity in Pakistani Population (SOPP), screening by whole-exome analysis found 3% had ...

J Clin Lipidol. 2021 Sep-Oct;15(5):682-689. PMID: 34593357 doi: 10.1016/j.jacl.2021.09.045Brief summary: This online survey of cardiologists and primary care physicians, conducted by the National Lipid Association, revealed the need to improve awareness, knowledge and treatment of heterozygous familial hypercholesterolemia (HeFH).Comment: HeFH is an autosomal dominan...

Nat Hum Behav. 2022;6(1):97-110. doi: 10.1038/s41562-021-01169-7. PubMed ID: 34413509Brief summary: This cross-sectional study of adults (N=702) aged 58–98 measured cognitive abilities across a range of domains (alerting, orienting and executive inhibitory networks) by use of a computer-based Attention Network Test. In non-linear regression models, while efficiency of the ale...

Nat Metab. 2021;3(11):1552-68. doi: 10.1038/s42255-021-00481-w.PubMed ID: 34697471Brief summary: This study identified a genetic locus on mouse chromosome 17, containing the gene Ndufv2, that controls mitochondrial mass and function in adipose tissue in a sex- and tissue-specific manner. In female mice, Ndufv2 regulated the expression of 89 mitochondrial genes, with invol...