ISSN 1662-4009 (online)

ey0017.7-7 | Basic Science | ESPEYB17

7.7. Environmentally relevant perinatal exposures to bisphenol A disrupt postnatal Kiss1/NKB neuronal maturation and puberty onset in female mice

F Ruiz-Pino , D Miceli , D Franssen , MJ Vazquez , A Farinetti , JM Castellano , G Panzica , M Tena-Sempere

To read the full abstract: Environmental health perspectives vol. 127,10 (2019): 107011. doi: https://ehp.niehs.nih.gov/doi/full/10.1289/EHP5570?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedThis study identifies the effects of exposure to environmentally rel...

ey0017.8-16 | New Paradigms | ESPEYB17

8.16. GDF15 is elevated in conditions of glucocorticoid deficiency and is modulated by glucocorticoid replacement

A Melvin , D Chantzichristos , CJ Kyle , SD Mackenzie , BR Walker , G Johannsson , RH Stimson , S O’Rahilly

To read the full abstract: J Clin Endocrinol Metab. 2020; 105(5): 1427–1434. PMID: 31853550.GDF15 is a stress-induced hormone that acts in the hindbrain to activate neural circuits involved in aversive responses and reducing food intake and body weight in animal models (1). In humans, GDF15 is widely expressed, with highest concentrations seen in placental trophoblasts, followed by kid...

ey0017.13-15 | Endocrinology | ESPEYB17

13.15. Adverse outcomes and economic burden of congenital adrenal hyperplasia late diagnosis in the newborn screening absence

de Miranda M Costa , Haddad L Bertocco de Paiva , G Madureira , B Bilharinho de Mendonca , TASS Bachega

To read the full abstract: J Endocrine Society 2020; 4 (2): 1–13. doi: 10.1210/jendso/bvz013• The authors performed a retrospective analysis of the economic burden in a cohort of 195 patients with genetically confirmed CAH born in São Paulo where there is presently no neonatal screening for CAH.• The cost associated to mortality of undiagnosed patients was estimated to ra...

ey0016.4-9 | New Perspectives | ESPEYB16

4.9. Low IGF-I bioavailability impairs growth and glucose metabolism in a mouse model of human PAPPA2 p.Ala1033Val mutation

M Fujimoto , M Andrew , L Liao , D Zhang , G Yildirim , P Sluss , B Kalra , A Kumar , S Yakar , V Hwa , A Dauber

To read the full abstract: Endocrinology. 2019;160:1363–1376.Pregnancy-associated plasma protein A2 (PAPP-A2) is a metalloproteinase which, by cleaving IGFBP-3 and IGFBP-5, releases free IGF-I from the ternary complexes and regulates its bioavailability. PAPPA2 gene mutations (p.D643fs25* and p.Ala1033Val) have recently been described in various members of two unrelated fam...

ey0016.8-4 | New Mechanisms | ESPEYB16

8.4. Associations between adrenarcheal hormones, amygdala functional connectivity and anxiety symptoms in children

MEA Barendse , JG Simmons , ML Byrne , G Patton , L Mundy , CA Olsson , ML Seal , NB Allen , S Whittle

To read the full abstract: Psychoneuroendocrinology. 2018; 97: 156–163.Anxiety disorders are common in childhood and adolescence and the transition from childhood to adolescence seems to be a vulnerable period for the development of anxiety symptoms. This article elucidates the impact of androgens (DHEA, DHEAS and testosterone) on functional connectivity of the amygdala while ...

ey0016.10-11 | (1) | ESPEYB16

10.11. Changes in diabetes medication regimens and glycemic control in adolescents and young adults with youth-onset type 2 diabetes: The SEARCH for diabetes in youth study

CA Pinto , JM Stafford , T Wang , RR Shankar , JM Lawrence , G Kim , C Pihoker , RB Jr D'Agostino , D Dabelea

Pediatr Diabetes. 2018 May 15. doi: 10.1111/pedi.12691There is a small but significant debate as to whether or not type 1 (T1D) and type 2 diabetes (T2D) are the same disease with albeit different course. It might therefore be prudent to include into a chapter on T1D a publication on T2D. This study aimed to describe recent medication patterns and changes in medication patterns and glycemic con...

ey0016.11-10 | Brown Adipose Tissue: The Story Goes On | ESPEYB16

11.10. Brown adipose tissue in prepubertal children: associations with sex, birthweight, and metabolic profile

R Malpique , JM Gallego-Escuredo , G Sebastiani , J Villarroya , A Lopez-Bermejo , F de Zegher , F Villarroya , L Ibanez

To read the full abstract: Int J Obes 2019; 43(2): 384–91Studies regarding brown adipose tissue (BAT) activity in children are scarce due to the difficulties in detecting BAT by imaging and the need for elaborate techniques to measure BAT activity. Here, prepubertal children born small for gestational age (SGA, n=41) and children born appropriate for gestational age (AGA, <...

ey0016.11-11 | Brown Adipose Tissue: The Story Goes On | ESPEYB16

11.11. Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues

A Raajendiran , G Ooi , J Bayliss , PE O'Brien , RB Schittenhelm , AK Clark , RA Taylor , MS Rodeheffer , PR Burton , MJ Watt

To read the full abstract: Cell Rep 2019; 27(5): 1528–40These authors used FACS cell sorting, gene expression profiling, and metabolic and proteomic analyses to identify three distinct adipocyte progenitor cell (APCs) subtypes that reside in human white adipose tissues. Although they retain comparable differentiation capacity, they have different molecular profiles and give rise to ...

ey0015.1-6 | New mechanisms | ESPEYB15

1.6 Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors

G Carreno , JR Apps , EJ Lodge , L Panousopoulos , S Haston , JM Gonzalez-Meljem , H Hahn , CL Andoniadou , JP Martinez-Barbera

To read the full abstract: Development 2017;144:3289-3302Aberrant development of the anterior pituitary can lead to congenital hypopituitarism (CH) in humans and hence understanding how this organ develops is critical to understand CH. The anterior pituitary develops in intimate contact with the prospective hypothalamus, which secretes growth factors that are required for the pituitary gland to grow...

ey0015.3-1 | Thyroid development | ESPEYB15

3.1 GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation

HS Kang , D Kumar , G Liao , K Lichti-Kaiser , K Gerrish , XH Liao , S Refetoff , R Jothi , AM Jetten

To read the full abstract: J Clin Invest 2017;127:4326-4337Mutations in the Krüppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) have first been associated with a syndrome combining two rare genetic endocrine diseases, namely neonatal diabetes and congenital hypothyroidism (OMIM #610199)1. Since then, 12 patients have been reported so far with a broad spect...