ISSN 1662-4009 (online)

ey0018.7-1 | Clinical Guidance | ESPEYB18

7.1. Cranial MRI abnormalities and long-term follow-up of the lesions in 770 girls with central precocious puberty

D Helvacıoğlu , S Demircioğlu Turan , T Guran , Z Atay , A Dağcınar , D Bezen , E Karakılıc Ozturan , F Darendeliler , A Yuksel , F Dursun , S Kılınc , S Semiz , S Abalı , M Yıldız , A Onder , A Bereket

J Clin Endocrinol Metab. 2021 Mar 25:dgab190. doi: 10.1210/clinem/dgab190. PMID: 33765130. https://academic.oup.com/jcem/article-abstract/106/7/e2557/6188450?redirectedFrom=fulltextIn brief: This multicentre cohort study explores the frequency, long-term outcomes and potential p...

ey0018.7-2 | Clinical Guidance | ESPEYB18

7.2. Genotype-phenotype correlations in central precocious puberty caused by MKRN3 mutations

CE Seraphim , APM Canton , L Montenegro , MR Piovesan , DB Macedo , M Cunha , A Guimaraes , CO Ramos , AFF Benedetti , A de Castro Leal , PC Gagliardi , SR Antonini , M Gryngarten , AJ Arcari , AP Abreu , UB Kaiser , L Soriano-Guillen , A Escribano- Munoz , R Corripio , JI Labarta , L Travieso-Suarez , NV Ortiz-Cabrera , J Argente , BB Mendonca , VN Brito , AC Latronico

J Clin Endocrinol Metab. 2021 Mar 25;106(4):1041–1050. 10.1210/clinem/dgaa955. PMID: 33383582. https://academic.oup.com/jcem/article-abstract/106/4/1041/6056669?redirectedFrom=fulltextIn brief: This paper describes the clinical and hormonal features of a large cohort of patients wit...

ey0018.7-3 | Clinical Guidance | ESPEYB18

7.3. Phase 3 trial of a small-volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty

KO Klein , A Freire , MG Gryngarten , GB Kletter , M Benson , BS Miller , TS Dajani , EA Eugster , N Mauras

J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3660–71. 10.1210/clinem/dgaa479. https://academic.oup.com/jcem/article/105/10/e3660/5879679In brief: This phase 3 multi-centre, open-label, single-arm study explores the efficacy, pharmacokinetics and safety of 6-monthly 45-mg subcutaneous leuprolide acetate in 59 pati...

ey0018.7-4 | Clinical Guidance | ESPEYB18

7.4. Marked increase in incident gynecomastia: A 20-year national registry study, 1998 to 2017

T Koch , EV Brauner , AS Busch , M Hickey , A Juul

J Clin Endocrinol Metab. 2020;105(10):dgaa440. 10.1210/clinem/dgaa440 https://academic.oup.com/jcem/article/105/10/3134/5868100In brief: Based on a 20-year Danish registry, this study reports a marked increase in incidence of gynecomastia between 1998 to 2017, 5-fold among post-pubertal males age 16–20 years, and ...

ey0018.7-5 | Clinical Guidance | ESPEYB18

7.5. Trends in the Incidence of central precocious puberty and normal variant puberty among children in denmark, 1998 to 2017

EV Brauner , AS Busch , C Eckert-Lind , T Koch , M Hickey , A Juul

JAMA Netw Open. 2020;3(10):e2015665. 10.1001/jamanetworkopen.2020.15665.. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2771377In brief: This Danish population-based 20-year cohort study provides strong epidemiological data supporting substantial increases in central precocious pub...

ey0018.7-6 | Clinical Guidance | ESPEYB18

7.6. GnRH stimulation testing and serum inhibin B in males: insufficient specificity for discriminating between congenital hypogonadotropic hypogonadism from constitutional delay of growth and puberty

H Mosbah , C Bouvattier , L Maione , S Trabado , G De Filippo , A Cartes , A Donzeau , P Chanson , S Brailly-Tabard , AA Dwyer , R Coutant , J Young

Hum Reprod. 2020 Oct 1;35(10):2312–2322. 10.1093/humrep/deaa185. PMID: 32862222. https://academic.oup.com/humrep/article/35/10/2312/5899242In brief: This study shows that both the GnRH stimulation test and serum inhibin B have insufficient specificity to discriminate congenital hypogonadotropic hypogonadism (CHH) from c...

ey0018.7-7 | Clinical Guidance | ESPEYB18

7.7. Prenatal exposure to maternal stressful life events and earlier age at menarche: the Raine study

EV Brauner , T Koch , A Juul , DA Doherty , R Hart , M Hickey

Hum Reprod. 2021 Jun 18;36(7):1959–1969. 10.1093/humrep/deab039 https://academic.oup.com/humrep/article-abstract/36/7/1959/6179308?redirectedFrom=fulltextIn brief: This large prospective population-based pregnancy cohort study identifies an association between maternal stressful li...

ey0018.7-8 | Basic Science | ESPEYB18

7.8. Oral contraceptive use, especially during puberty, alters resting state functional connectivity

R Sharma , Z Fang , A Smith , N Ismail

Horm Behav. 2020;126:104849. 10.1016/j.yhbeh.2020.104849. https://www.sciencedirect.com/science/article/abs/pii/S0018506X20301756?via%3DihubIn brief: This study used functional MRI to compare resting state functional connectivity in women who started oral contraception during puberty or ad...

ey0018.7-9 | Basic Science | ESPEYB18

7.9. ER[alpha] signaling in GHRH/Kiss1 dual-phenotype neurons plays sex-specific roles in growth and puberty

D Garcia-Galiano , AL Cara , Z Tata , SJ Allen , MG Jr Myers , E Schipani , CF Elias

J Neurosci. 2020 Dec 2;40(49):9455–9466. 10.1523/JNEUROSCI.2069-20.2020. PMID: 33158965 https://www.jneurosci.org/content/40/49/9455.longIn brief: These authors used two transgenic mouse models to assess the direct action of estrogens and androgens on GHRH neurons to control growth, pubertal development and reprod...

ey0018.7-10 | Basic Science | ESPEYB18

7.10. Central ceramide signaling mediates obesity-induced precocious Puberty

V Heras , JM Castellano , D Fernandois , I Velasco , E Rodriguez-Vazquez , J Roa , MJ Vazquez , F Ruiz-Pino , M Rubio , R Pineda , E Torres , MS Avendano , A Paredes , L Pinilla , D Belsham , C Dieguez , F Gaytan , N Casals , M Lopez , M Tena-Sempere

Cell Metab. 2020 Dec 1;32(6):951–966.e8. 10.1016/j.cmet.2020.10.001. PMID: 33080217. https://www.sciencedirect.com/science/article/pii/S1550413120305349?via%3DihubIn brief: This study reveals the critical role of hypothalamic ceramide synthesis in the induction of precocious puberty in obe...