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ey0017.9-3 | Fertility-Related Issues | ESPEYB17

9.3. The influence of different intensity of treatment on hormonal markers of gonadal function in acute lymphoblastic leukemia survivors

M Krawczuk-Rybak , M Płonowski , E Leszczyńska , E Latoch , M Sawicka-Żukowska , K Muszyńska-Rosłan , J Skalska-Sadowska , J Wachowiak , D Sga-Pondel , B Kazanowska , A Chybicka , T Stachowicz-Stencel , J Stefanowicz , I Malinowska , M Matysiak , A Kotan , M Wysocki , A Pobudejska-Piena¸żek , T Szczepański , B Przybyszewski , W Badowska , D Szymańska-Miller , JR Kowalczyk , E Kamieńska , T Urasiński , A Wawrzeńczyk , B Żelazowska-Rutkowska , B Cylwik

To read the full abstract: Hematol Oncol. 2019 Dec;37(5):609616. mar26@mp.plAcute lymphoblastic leukaemia (ALL) is the most common childhood neoplasia with an actual survival rate >80%. ALL treatment has changed considerably during last 30 years; radiotherapy with 24 Gy to the central nervous system (CNS) has been eliminated or reduced to lower doses (12 or 18 Gy) and chemotherapy regimens are now tailo...

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ey0015.10-10 | Continuous glucose monitoring, insulin pumps and artificial pancreas | ESPEYB15

10.10 International consensus on use of continuous glucose monitoring

T Danne , R Nimri , T Battelino , RM Bergenstal , KL Close , JH DeVries , S Garg , L Heinemann , I Hirsch , SA Amiel , R Beck , E Bosi , B Buckingham , C Cobelli , E Dassau , FJ Doyle , S Heller , R Hovorka , W Jia , T Jones , O Kordonouri , B Kovatchev , A Kowalski , L Laffel , D Maahs , HR Murphy , K Nørgaard , CG Parkin , E Renard , B Saboo , M Scharf , WV Tamborlane , SA Weinzimer , M Phillip

To read the full abstract: Diabetes Care. 2017;40:1631-1640[Comments on 10.9 and 10.10] These two publications describe guidelines made by the international learned societies on the use of continuous glucose monitoring devices. It is important to learn from these publications that education and guidance are pivotal before continuous glucose...

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ey0018.2-7 | Neonatal hypoglycaemia | ESPEYB18

2.7. Possible new strategies for the treatment of congenital hyperinsulinism

J Sikimic , T Hoffmeister , A Gresch , J Kaiser , W Barthlen , C Wolke , I Wieland , U Lendeckel , P Krippeit-Drews , M Dufer , G Drews

Front Endocrinol (Lausanne). 2020 Oct 27;11:545638. doi: 10.3389/fendo.2020.545638. PMID: 33193079.Using human islets from CHI patients and islets from ABCC8 (SUR1) knockout mice, the authors tested several novel compounds to inhibit insulin over-secretion. These novel compounds targeted KATP channels as well as KATP indepe...

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ey0018.3-5 | Drug induced thyroid disease | ESPEYB18

3.5. Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade

Z Khan , C Hammer , J Carroll , F Di Nucci , SL Acosta , V Maiya , T Bhangale , J Hunkapiller , I Mellman , ML Albert , MI McCarthy , GS Chandler

Nat Commun. 2021 Jun 7;12(1):3355. doi: 10.1038/s41467-021-23661-4.This study describes the interaction of individual genetic variation for autoimmune thyroid disease with risk of thyroid immune related adverse events (irAE) during or after immune checkpoint inhibitor (ICI) treatment for advanced cancer.ICIs are monoclonal antibodies blocking T-cell exhaustion and...

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ey0018.6-3 | Basic and Genetic Research of DSD | ESPEYB18

6.3. The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome

E Ilaslan , R Markosyan , P Sproll , BJ Stevenson , M Sajek , MP Sajek , H Hayrapetyan , T Sarkisian , L Livshits , S Nef , J Jaruzelska , K Kusz-Zamelczyk

Int J Mol Sci. 2020 Nov 9;21(21):8403. doi: 10.3390/ijms21218403. PMID: 33182400This case report describes a patient with clinically diagnosed partial androgen insensitivity syndrome (PAIS). However, no mutation in the androgen receptor gene was identified. Instead, whole genome sequencing revealed a heterozygous point mutation inherited from the mother in the FKBP4 gene. This gene i...

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ey0018.6-16 | Longterm Effects of Hormonal Treatments in Gender Dysphoria | ESPEYB18

6.16. Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

A Weill , P Nguyen , M Labidi , B Cadier , T Passeri , L Duranteau , AL Bernat , I Yoldjian , S Fontanel , S Froelich , J Coste

BMJ. 2021 Feb 3;372:n37. doi: 10.1136/bmj.n37. PMID: 33536184This observational cohort study used data from the French administrative healthcare database during 20072015 to assess the risk of meningioma development related to treatment with cyproterone acetate. The cohort comprised 253,777 participants, of whom 54% had high exposure to cyproterone acetate, and 45% had low exposure.<p cla...

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ey0018.9-10 | Reproductive outcomes in childhood cancer survivors | ESPEYB18

9.10. Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies.

G Sommerhauser , A Borgmann-Staudt , K Astrahantseff , K Baust , G Calaminus , R Dittrich , MJ Fernandez-Gonzalez , H Holling , CJ Konig , R Schilling , T Schuster , L Lotz , M Balcerek

J Cancer Surviv. 2021; 15: 259272. https://pubmed.ncbi.nlm.nih.gov/32844376/Long-term treatment effects are possible reasons for reduced fertility and adverse pregnancy outcomes in childhood cancer survivors (CCS) (1). This observational study reports perinatal and health outcomes of offspring born to CCS using assisted reproductive technologies (ART). CCS were almost 2-fold more like...

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ey0018.10-1 | (1) | ESPEYB18

10.1. Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany?

SR Tittel , J Rosenbauer , C Kamrath , J Ziegler , F Reschke , J Hammersen , K Monkemoller , A Pappa , T Kapellen , RW Holl , Initiative DPV

Diabetes Care. 2020;43(11):e172e173. doi: 10.2337/dc20-1633During the first phase of the COVID-19 pandemic, the DPV (the German diabetes registry database) study group asked whether or not the COVID-19 lockdown had affected the incidence of pediatric T1D in Germany (1). More than 210 German pediatric diabetes centers contributed their data on pediatric patients with T1D with an onset at ag...

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ey0018.11-12 | Criticism of the previous BMI metrics for use in severely obese children | ESPEYB18

11.12. A longitudinal comparison of alternatives to body mass index Z-Scores for children with very high body mass indexes

DS Freedman , AJ Goodwin Davies , L Kompaniyets , SJ Lange , AB Goodman , T Tam Phan , FS Cole , A Dempsey , N Pajor , I Eneli , DA Christakis , CB Forrest

J Pediatr. 2021 Mar 5;S0022-3476(21)00211-0. https://pubmed.ncbi.nlm.nih.gov/33676932/The authors analysed BMI data from 10.8 million children and adolescents from the PEDSnet database (USA), collected longitudinally between 1999-2019, to examine the tracking of various BMI metrics (BMIz, BMImz, BMIz extended, %BMIp95, %BMIp50,%BMIp50 adjusted| calculated according to CDC growth char...

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ey0019.1-13 | Clinical Papers | ESPEYB19

1.13. Management of children and young people with idiopathic pituitary stalk thickening, central diabetes insipidus, or both: a national clinical practice consensus guideline.

M Cerbone , J Visser , C Bulwer , A Ederies , K Vallabhaneni , S Ball , I Kamaly-Asl , A Grossman , H Gleeson , M Korbonits , V Nanduri , V Tziaferi , T Jacques , HA Spoudeas

Lancet Child Adolesc Health. 2021 Sep;5(9):662-676. doi: 10.1016/S2352-4642(21)00088-2. Epub 2021 Jun 30; PMID: 34214482.Brief Summary: This comprehensive guideline defines the role of cerebrospinal fluid tumor markers, whole-body imaging, and the indications, timing and risks of stalk biopsy, as well as criteria for discharge in children and young people with idiopathic pituitary stalk...

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ESPE Yearbook of Paediatric Endocrinology

9.3. The influence of different intensity of treatment on hormonal markers of gonadal function in acute lymphoblastic leukemia survivors

10.10 International consensus on use of continuous glucose monitoring

2.7. Possible new strategies for the treatment of congenital hyperinsulinism

3.5. Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade

6.3. The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome

6.16. Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

9.10. Health outcomes in offspring born to survivors of childhood cancers following assisted reproductive technologies.

10.1. Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany?

11.12. A longitudinal comparison of alternatives to body mass index Z-Scores for children with very high body mass indexes

1.13. Management of children and young people with idiopathic pituitary stalk thickening, central diabetes insipidus, or both: a national clinical practice consensus guideline.

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