ISSN 1662-4009 (online)

ey0019.7-8 | Basic Science | ESPEYB19

7.8. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

G Pellegrino , M Martin , C Allet , T Lhomme , S Geller , D Franssen , V Mansuy , M Manfredi-Lozano , A Coutteau-Robles , V Delli , S Rasika , D Mazur , A Loyens , M Tena-Sempere , J Siepmann , FP Pralong , P Ciofi , G Corfas , AS Parent , SR Ojeda , A Sharif , V Prevot

Nat Neurosci. 2021 Dec;24(12):1660-1672. doi: 10.1038/s41593-021-00960-z. Epub 2021 Nov 18. PMID: 34795451. https://www.nature.com/articles/s41593-021-00960-zBrief Summary: This neuroanatomical and physiological study in mice demonstrates that GnRH neurons attract glial cells in their vicinity via cell–cell communication...

ey0019.7-10 | Basic Science | ESPEYB19

7.10. The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

K Skrapits , M Sarvari , I Farkas , B Gocz , S Takacs , E Rumpler , V Vaczi , C Vastagh , G Racz , A Matolcsy , N Solymosi , S Poliska , B Toth , F Erdelyi , G Szabo , MD Culler , C Allet , L Cotellessa , V Prevot , P Giacobini , E Hrabovszky

Elife. 2021 Jun 15;10:e67714. doi: 10.7554/eLife.67714. PMID: 34128468https://elifesciences.org/articles/67714Brief Summary: This histological and transcriptomic study evaluates the presence and the potential role of extra-hypothalamic GnRH neurons in humans and identifies cholinergic GnRH-synthesizing cells in the human basal...

ey0017.5-12 | Advances in Skeletal Biology | ESPEYB17

5.12. Lipid availability determines fate of skeletal progenitor cells via SOX9

N van Gastel , S Stegen , G Eelen , S Schoors , A Carlier , VW Daniels , N Baryawno , D Przybylski , M Depypere , PJ Stiers , D Lambrechts , R Van Looveren , S Torrekens , A Sharda , P Agostinis , D Lambrechts , F Maes , JV Swinnen , L Geris , H Van Oosterwyck , B Thienpont , P Carmeliet , DT Scadden , G Carmeliet

To read the full abstract: Nature 2020;579:111–117.In brief: In large fracture calluses, skeletal progenitors activate the chondrogenesis program, whereas in smaller calluses, direct osteogenesis is the preferred path. Here, the authors show that lipid availability determines whether skeletal stem cells repair a fracture through endochondral bone formation or direct ossificati...

ey0017.8-3 | Important for Clinical Practice | ESPEYB17

8.3. Frequency and incidence of Carney complex manifestations: A prospective multicenter study with a three-year follow-up

S Espiard , MC Vantyghem , G Assie , C Cardot-Bauters , G Raverot , F Brucker-Davis , F Archambeaud-Mouveroux , H Lefebvre , ML Nunes , A Tabarin , A Lienhardt , O Chabre , M Houang , M Bottineau , S Stroer , L Groussin , L Guignat , L Cabanes , A Feydy , F Bonnet , MO North , N Dupin , S Grabar , D Duboc , J Bertherat

To read the full abstract: J Clin Endocrinol Metab. 2020; 105(3): dgaa002. PMID: 31912137.Carney complex (CNC) is a rare multiple endocrine and nonendocrine neoplasia syndrome, described in 1985 by J. Aidan Carney (1). The diagnostic criteria include dermatologic manifestations (spotty skin pigmentation with typical periorificial distribution [known as lentigines], cutaneou...

ey0016.14-9 | (1) | ESPEYB16

14.9. Did our species evolve in subdivided populations across Africa, and Why does it matter?

Scerri Eleanor M.L. , Thomas Mark G. , Manica Andrea , Gunz Philipp , Stock Jay T. , Stringer Chris , Grove Matt , Groucutt Huw S. , Timmermann Axel , Rightmire G. Philip , d'Errico Francesco , Tryon Christian A. , Drake Nick A. , Brooks Alison S. , Dennell Robin W. , Durbin Richard , Henn Brenna M. , Lee-Thorp Julia , deMenocal Peter , Petraglia Michael D. , Thompson Jessica C. , Scally Aylwyn , Chikhi Lounes

To read the full abstract: Trends in Ecology & Evolution, 2018. 33 (8); 582–594.This opinion piece argues that Homo sapiens evolved within interlinked groups living across Africa, and not in a single region of East Africa. Millennia of separation gave rise to diversity of human forms, and a complex mix of archaic and modern features in different places and...

ey0016.14-12 | (1) | ESPEYB16

14.12. Genome amplification and cellular senescence are hallmarks of human placenta development

P Velicky , G Meinhardt , K Plessl , S Vondra , T Weiss , P Haslinger , T Lendl , K Aumayr , M Mairhofer , X Zhu , B Schutz , RL Hannibal , R Lindau , B Weil , J Ernerudh , J Neesen , G Egger , M Mikula , C Rohrl , AE Urban , J Baker , M Knofler , J Pollheimer

To read the full abstract: PLoS Genet 2018;14:e1007698.These authors studied human placental and decidual tissues obtained from elective pregnancy terminations (6–12 weeks gestation). Placental extravillous trophoblasts (EVTs), the cells that rapidly invade the mother’s endometrium, undergo an initial stage of genomewide amplification leadi...

ey0020.7-7 | Gonadal Function and Fertility Issues in Childhood Cancer Survivors | ESPEYB20

7.7. The uterine volume is dramatically decreased after hematopoietic stem cell transplantation during childhood regardless of the conditioning regimen

B Courbiere , B Drikes , A Grob , Z Hamidou , P Saultier , Y Bertrand , V Gandemer , D Plantaz , G Plat , M Poiree , S Ducassou , C Pochon , JH Dalle , S Thouvenin , C Paillard , J Kanold , A Sirvent , C Rousset-Jablonski , S Duros , A Gueniffey , C Cohade , S Boukaidi , S Frantz , M Agopiantz , C Poirot , A Genod , O Pirrello , AS Gremeau , S Bringer-Deutsch , P Auquier , G Michel

Brief summary: This French multicenter prospective study analyzed uterine volume by pelvic MRI in 88 women (age range 18–40 years), who were survivors of childhood acute leukemia treated with hematopoietic stem cell transplantation (HSCT). They were compared to 88 healthy women matched for age and parity.Conditioning regimens before HSCT included alkylating agents for 34 women and total body irradiation (TBI) for 54 women. Scans were centralized and...

ey0020.8-10 | New Paradigms | ESPEYB20

8.10. Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

X Yuan , R Wang , B Han , C Sun , R Chen , H Wei , L Chen , H Du , G Li , Y Yang , X Chen , L Cui , Z Xu , J Fu , J Wu , W Gu , Z Chen , X Fang , H Yang , Z Su , J Wu , Q Li , M Zhang , Y Zhou , L Zhang , G Ji , F Luo

Brief summary: Using in-depth multi-omics analyses of human type 1 diabetes (T1D) samples, the authors profiled gut microbial functional and metabolic alterations. The T1D microbiota showed decreased butyrate production and bile acid metabolism and increased lipopolysaccharide (LPS) biosynthesis. Fecal microbiota transplantation in animal models proved that T1D gut microflora is a causative factor in the regulation of glucose metabolism.The etiology of T...