ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This study investigated the effects of anorexia nervosa (AN) on the insulin-like growth factor (IGF) axis in female adolescents. It evaluated levels of various proteins and their role in the IGF axis, including pregnancy-associated plasma protein A2 (PAPP-A2) and stanniocalcins (STC-1 and STC-2). The reduced levels of PAPP-A2 may impair IGFBP cleavage, thereby reducing IGF-I bioavailability. IGF1 plays a crucial role in regulating growth, metabolism, and bone he...

Preface: As in previous years in this Yearbook 2024 chapter we can only present 1.5 % of the acquired publications (1,656) according to our search criteria in PubMed. The last year has again been extremely exciting for the field of obesity and weight regulation and it was a significant step into the future in terms of scientific output.Of particular importance is the new pharmacological therapeutic approach for patients with acquired hypothalamic obesity...

N Engl J Med 2021; 384:1113–1124. DOI: 10.1056/NEJMoa2028395 https://www.nejm.org/doi/full/10.1056/NEJMoa2028395The authors report a 72-week, double-blind placebo-controlled trial in 320 adult patients with biopsy-confirmed nonalcoholic steatohepatitis (NASH) and liver fibrosis (stage F1, F2, or F3). Patients were randomly assig...

Environ Health Perspect.2021 Aug;129(8):87003. doi: 10.1289/EHP8795. Epub 2021 Aug 12. PMID: 34383603. https://ehp.niehs.nih.gov/doi/10.1289/EHP8795?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedBrief Summary: Using a rode...

To read the full abstract: Proc Natl Acad Sci U S A. 2019, Dec 3; 116: 24480-5. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900519/pdf/pnas.201909367.pdfIn a large sample of 317 US American transgender children aged 3–12 years, the authors compared gender outcomes of transgender children with cisgender peers. They also assessed whether the time ...

To read the full abstract: N Engl J Med 2018;378:1987-1998FGF-23 is the primary regulator of phosphate homeostasis and acts by inhibiting phosphate reabsorption in the kidney (1). Loss-of-function mutations in the gene encoding phosphate-regulating endopeptidase homolog X-linked (PHEX) results in excess circulating FGF-23, which impairs renal phosphate reabsorption causing hypophosphatemia...

To read the full abstract: Nature 2017, 542, 450–455Adipose tissue is no longer considered a passive energy store. Instead, it is well established as an important endocrine contributor. Here, the authors comprehensively show that the function of the adipose tissue as an endocrine organ is not limited to classical adipokines, but also includes miRNAs and maybe other non-coding RNAs. This study...

Brief summary: In this study, 10 145 children of 1–8 years of age, selected from a prospective systematic cohort study and stratified according to HLA-risk categories for type-1-diabetes (T1D), underwent a combined evaluation of pancreatic autoimmunity, glucose metabolism and anthropometry at different timeframes. Diagnosis of T1D occurred in 131/10,145 children (1.3%). Faster height growth, both before and after age 3 years, was significantly associated with the appearan...

NIDDK Type 1 Diabetes TrialNet Study Group.Diabetes. 2022 Apr 1;71(4):610-623. https://pubmed.ncbi.nlm.nih.gov/35316839/Brief Summary: This is a comprehensive review on general population screening, a current hot topic in the field of type 1 diabetes (T1D). The authors provide a critical overview of the rationale for population screening, arguments for and against it, current efforts to gui...

To read the full abstract: Science 2019;365:eaat7693.These authors performed a genome-wide association study on 493 001 participants of European-ancestry from the USA, UK, and Sweden to identify genes associated with sexual orientation. They found multiple loci implicated in same-sex sexual behavior indicating that, like other behavioral traits, non-heterosexual behavior is polygenic.As many as 4% to 10% of US individuals ...