ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This systematic review examined the impact of at least one trimester of pregnancy glucocorticoid treatment on pregnancy, neonatal and child outcomes. It included human studies published after 2000 (to 2022) to avoid earlier work where maternal and newborn care may have been outdated. It identified 23 eligible papers, most described cohort studies (not all had control groups), 3 case reports or series and one meta-analysis of dexamethasone (DEX) to prevent virili...

Brief Summary: This single-center, prospective study used brain MRI to assess the prevalence of cerebrovascular abnormalities in a large cohort of adult patients born SGA and treated with GH during childhood, 12 years after rhGH treatment cessation. GH treatment was not associated with a higher incidence of aneurysms, intracerebral hemorrhages, microbleeds or other vascular abnormalities.The French population-based cohort of the Safety and Appropriatenes...

Brief Summary: This systematic review and meta-analysis included 22 studies, with a total of 19,893 transgender women, 14,840 transgender men, 371,547 cisgender men, and 434,700 cisgender women, to assess the occurrence of cardiovascular events. The risk of the combined outcome (stroke, myocardial infarction or thrombosis) was 40% higher in transgender people compared to cisgender people of the same birth-registered sex.Gender-affirming therapy may play ...

To read the full abstract: J Cancer Res Clin Oncol. 2020 Jun;146(6):1451–1462. marloes.vandijk@amsterdamumc.nlChemo- and radiotherapy administered during childhood may compromise female reproductive function leading to premature depletion of the ovarian follicle pool. Childhood cancer survivors (CCS) women who pursue pregnancy may experience a lengthening of the time required to become pr...

Hum Reprod. 2018 Jul 6. [Epub ahead of print]. doi: 10.1093/humrep/dey229Childhood cancer treatment may compromise ovarian function in female childhood cancer survivors (CCSs), leading to delayed or arrested puberty, infertility, subfertility and adverse pregnancy outcomes. This Dutch nationwide retrospective cohort study collected measurements performed between 2008 and 2...

Brief Summary: This study describes the clinical characteristics of pathogenic variants in the ACAN gene and the response to rhGH treatment over three years in children with a heterozygous ACAN variant. The results indicate that rhGH therapy may be considered to reduce the height deficit in these patients, particularly in prepubertal children with ACAN deficiency.Aggrecan is the major proteoglycan of the cartilage growth plate. Homozygo...

Brief Summary:This study tested the discriminatory role of 11-oxygenated androgens to diagnose PCOS in women with obesity, and with ( n =132) or without ( n =83) PCOS. No discriminatory role was found. Instead, insulin resistance, blood pressure, obesity and androgens were the principal components characterizing obese PCOS, while no major characteristic finding defined obese non-PCOS women.Numerous studies have addressed the mechanism o...

J Pediatr Adolesc Gynecol. 2021 Apr;34(2):176–189.e2. doi: 10.1016/j.jpag.2020.11.001 https://www.ncbi.nlm.nih.gov/pubmed/33181339This study explores the well-being and sexual health needs of contemporary youth with a DSD. It is a small scale, mixed methods study by specialized DSD psychologists-sexologists in a sample of w...

s.l.s.drop@erasmusmc.nl J Am Medical Informatics Assoc 2022; 29: 713–722. doi: 10.1093/jamia/ocab271Brief Summary: This scoping review found that data remain scarce on the potential synergy between e-learning (EL) training for healthcare workers (HCWs) and provider-to-HCW e-consultation (EC).Both e-learning (EL) training ...

To read the full abstract: Eur J Endocrinol 2017;177:D1-D12Newborn screening (NBS) is an invaluable tool for identification of CH; however almost 70% of newborns worldwide do not benefit from NBS at all. In countries with NBS, lowering of TSH cut-offs over the years led to major controversy on the optimal TSH screening cut-off. In this very interesting debate paper, arguments are presented f...