ISSN 1662-4009 (online)

ey0018.2-15 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB18

2.15. Gestational diabetes Is uniquely associated with altered early seeding of the infant gut microbiota

TK Soderborg , CM Carpenter , RC Janssen , TL Weir , CE Robertson , D Ir , BE Young , NF Krebs , TL Hernandez , LA Barbour , DN Frank , M Kroehl , JE Friedman

Front Endocrinol (Lausanne). 2020 Nov 27;11:603021. doi: 10.3389/fendo.2020.603021. PMID: 33329403.This and previous studies have shown that Gestational diabetes mellitus (GDM) alone and maternal obesity/overweight are associated with alterations in the newborn gut microbiota. In this study, there were significant alterations in the newborn gut microbiota species at 2 weeks of age.<p...

ey0017.11-15 | New Insight into Bariatric Surgery | ESPEYB17

11.15. 5-year mental health and eating pattern outcomes following bariatric surgery in adolescents: a prospective cohort study

Jarvholm , G Bruze , M Peltonen , C Marcus , CE Flodmark , P Henfridsson , AJ Beamish , E Gronowitz , J Dahlgren , J Karlsson , T Olbers

To read the full abstract: Lancet Child Adolesc Health. 2020;4(3):210–19. PMID 31978372.In this non-randomized matched-control study, 81 obese adolescents undergoing Roux-en-Y gastric bypass surgery (RYGB) who participated in the Adolescent Morbid Obesity Surgery (AMOS) study (11) were compared with 80 obese controls from the Swedish Childhood Obesity Treatment Register (BORIS) who rec...

ey0016.2-1 | Neonatal Hypoglycaemia | ESPEYB16

2.1. Congenital hyperinsulinism in infants with turner syndrome: possible association with monosomy X and KDM6A haploinsufficiency

CE Gibson , KE Boodhansingh , C Li , L Conlin , P Chen , SA Becker , T Bhatti , V Bamba , NS Adzick , DD De Leon , A Ganguly , CA Stanley

To read the full abstract: Horm Res Paediatr: 2018;89(6):413–422.This study examined the clinical and molecular aspects of girls with Turner syndrome and hyperinsulinaemic hypoglycemia (HH). Records of girls with hyperinsulinism and Turner syndrome were reviewed.The findings expand on previous observations suggesting a link between Turner syndrome and hyperins...

ey0016.9-7 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.7. No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment

FN Belle , R Kasteler , C Schindera , M Bochud , RA Ammann , NX von der Weid , CE Kuehni , Swiss Pediatric Oncology Group (SPOG)

To read the full abstract: Cancer. 2018 Sep 1; 124 (17): 3576.Glucocorticoids still represent one of the pillars in the treatment of paediatric hematologic malignancies, but they cause excessive weight gain through several mechanisms. However, it is unclear whether these glucocorticoids have a long-lasting effect on body weight, because studies have focused mainly on the acute effects du...

ey0015.7-9 | Genetic architecture of hypogonadotropic hypogonadism and delayed puberty | ESPEYB15

7.9 Contributions of Function-Altering Variants in Genes Implicated in Pubertal Timing and Body Mass for Self-Limited Delayed Puberty

SR Howard , L Guasti , A Poliandri , A David , CP Cabrera , MR Barnes , K Wehkalampi , S O'Rahilly , CE Aiken , AP Coll , M Ma , D Rimmington , GSH Yeo , L Dunkel

To read the full abstract: J Clin Endocrinol Metab. 2018 Feb 1;103(2):649-659A minimum level of energy availability is required for the onset of puberty, whereas increased fat mass has been shown to be associated with precocious onset of puberty1,2. Recent genome-wide association studies have identified several loci for age at menarche also associated with obesity3-5. Whethe...

ey0021.6-5 | Clinical and Molecular Insights into SF1 Deficiency | ESPEYB21

6.5. Clinical and genetic characteristics of a large international cohort of individuals with rare NR5A1 /SF-1 variants of sex development

C Kouri , G Sommer , I Martinez de Lapiscina , RN Elzenaty , LJW Tack , M Cools , SF Ahmed , CE; SF1next study group Fluck

Brief Summary: The SF1next study describes a cohort of 197 individuals with NR5A1 / SF-1 variants, identified through the I-DSD registry and a research network involving 55 centers across 18 countries. NR5A1/SF-1 plays a crucial role in the development and function of human sex and steroid producing organs, and variants in this gene can significantly affect early sex determination and differentiation. This can lead to a wide spectrum of differences i...

ey0021.13-7 | Endocrinology | ESPEYB21

13.7. Vitamin D supplements for fracture prevention in schoolchildren in Mongolia: analysis of secondary outcomes from a multicentre, double-blind, randomised, placebo-controlled trial

D Ganmaa , P Khudyakov , U Buyanjargal , E Tserenkhuu , S Erdenenbaatar , CE Achtai , N Yansanjav , B Delgererekh , M Ankhbat , E Tsendjav , B Ochirbat , B Jargalsaikhan , D Enkhmaa , AR Martineau

Brief Summary: This multicenter, double-blind, randomized, placebo-controlled trial evaluated the effects of vitamin D supplementation (14,000 IU D3 weekly for 3 years) on fracture risk and other bone health indicators in 8,851 schoolchildren aged 6–13 years in 18 public schools in Mongolia, where vitamin D deficiency is highly prevalent with a high fracture burden.Vitamin D3 doses were given during weekly face-to-face visits in schools. Families co...

ey0018.11-5 | New hope: Increased diagnostic yield for disease causing MC4R variants and pharmacological treatment options | ESPEYB18

11.5. Obesity treatment effect in danish children and adolescents carrying melanocortin-4 receptor mutations

C Trier , M Hollensted , TM Schnurr , MAV Lund , TRH Nielsen , G Rui , EA Andersson , M Svendstrup , DS Bille , AP Gjesing , CE Fonvig , C Frithioff-Bojsoe , M Balslev-Harder , S Quan , M Gamborg , O Pedersen , L Angquist , JC Holm , T Hansen

Int J Obes (Lond). 2021;45(1):66–76. doi: https://doi.org/10.1038/s41366-020-00673-6This study investigated the influence of MC4R variants on treatment effectiveness in a large cohort undergoing an outpatient treatment program. Carriers of MC4R loss-of-function (LoF) variants showed a lack of improvement in BMI, in contrast to non LoF carriers.As we learn th...

ey0019.11-6 | New findings in adipose tissue biology | ESPEYB19

11.6. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

Q Li , CE Hagberg , HS Cascales , S Lang , MT Hyvonen , F Salehzadeh , P Chen , I Alexandersson , E Terezaki , MJ Harms , M Kutschke , N Arifen , N Kramer , M Aouadi , C Knibbe , J Boucher , A Thorell , KL Spalding

kirsty.spalding@ki.se Nat Med 2021; 27(11): 1941–1953 doi: 10.1038/s41591-021-01501-8Brief Summary: This study analysed adipocytes from obese and hyperinsulinemic adults. They demonstrate that obesity is associated with the induction of a cell cycle program in mature adipocytes, leading to so-called endoreplication, as a strategy to remain fu...

ey0019.15-17 | Basic Science and Genetics | ESPEYB19

15.17. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

Krishnan K Chella , L Vergnes , R Acin-Perez , L Stiles , M Shum , L Ma , E Mouisel , C Pan , TM Moore , M Peterfy , CE Romanoski , K Reue , JLM Bjorkegren , M Laakso , M Liesa , AJ Lusis

Nat Metab. 2021;3(11):1552-68. doi: 10.1038/s42255-021-00481-w.PubMed ID: 34697471Brief summary: This study identified a genetic locus on mouse chromosome 17, containing the gene Ndufv2, that controls mitochondrial mass and function in adipose tissue in a sex- and tissue-specific manner. In female mice, Ndufv2 regulated the expression of 89 mitochondrial genes, with invol...