ESPE Yearbook of Paediatric Endocrinology

Brief summary: This study used a Delphi approach to generate consensus guidelines for screening of asymptomatic childhood cancer survivors for thyroid dysfunction and recommendations for the management of abnormal thyroid screening results.A Delphi panel of 40 clinical experts (oncologists, endocrinologists, and primary care physicians) participated in three rounds of anonymous questionnaires, formatted as clinical scenarios. Consensus was defined by agr...

To read the full abstract: J Clin Endocrinol Metab. 2019 Dec 1;104(12):5737–5750. doi: 10.1210/jc.2019-00631. PMID: 31504653.This paper describes two genes and three syndromes that clinicians would probably like to know when treating patients with a syndromic form of panhypopituitarism. Heterozygous mutation in a maternally imprinted gene, MAGEL2, was described in four patients...

To read the full abstract: J Pediatr 2018;196:208-216.e2Insulin deficiency or resistance activates intracellular hormone-sensitive lipase; this increases the release of non-esterified fatty acids from triglycerides stored in centrally distributed adipose tissue. High circulating levels of non-esterified fatty acids increase hepatic triglyceride synthesis, which in turn increases secretion o...

Brief summary: This study aimed to decipher the pathophysiology of the lower prevalence of diabetic retinopathy observed among youth with T2D who also have severe obesity. None of the several biomarkers assessed was found to be associated with the obesity paradox. The biomarkers included: inflammatory factors, acute phase reactants or cytokines (VEGF, hsCRP, ICAM-1, VCAM-1, homocysteine, adiponectin, E-selectin, MCP-1, TNF-α, IL-6, fibrinogen, and ApoB).<p class="abst...

Brief Summary: This double-blind, placebo-controlled international trial, randomized overweight and obese adults with T2D to either once-weekly subcutaneous Tirzepatide (10 mg or 15 mg) or placebo for 72 weeks. Tirzepatide led to weight reductions of -9.6% with the 10 mg dose and -11.6% with the 15 mg dose, compared to placebo. From a mean baseline 8.0%, HbA1c reduced by –2·1% with both the 10 mg, and 15 mg dose of triszepatied compared to 0·5% reduction on plac...

Lancet Glob Health 2019;7: e132–47. DOI: 10.1093/cid/civ844• This cluster-randomised, community-based trial investigates whether the combination of a water, sanitation and hygiene (WASH) intervention and of improved infant and young child feeding (IYCF) intervention improves stunting and anemia in children living in rural Zimbabwe.• Stunting decreased with ...

To read the full abstract: Sci Rep 2017; 16;7:15693SRS is a rare congenital disorder, characterized by intrauterine growth restriction, postnatal growth impairment and a wide range of signs and symptoms such as dysmorphic features, severe feeding difficulties, body asymmetry, and neurodevelopmental delay. The molecular etiology is heterogeneous. Loss of methylation on chromosome 11p1...

To read the full abstract: J Pediatr Gastroenterol Nutr. 2017;65:293-298Growth deceleration and impaired pubertal growth spurt are common concerns in patients with early onset inflammatory bowel disease (IBD) (1-2). Previous studies confirmed the efficacy and safety of infliximab, an anti-tumor necrosis factor alpha (TNF-α) antibody, in achieving clinical remission in luminal Crohn&#8...

To read the full abstract: Cell Metab. 2017, Volume 26, Issue 1 Riera et al. developed ways to temporarily eliminate the sense of smell in adult mice. They discovered that mice lacking smell could eat a high-fat diet and stay significantly thinner than littermates with a normal sense of smell. Conversely, mice with hyperosmia gained more weight than wild-type mice on a high-fat diet. ...

Brief summary: The incidences of T1D and T2D in children and young people increased in the USA over the last 2 decades. For the first time, the incidence of T2D has surpassed that of T1D.Comment: The SEARCH study has served as a national resource to explore the epidemiology and consequences of diabetes in the US. Published over the years, the findings contribute to understanding future trends in other parts of the world. Overall, the current report shows...