ISSN 1662-4009 (online)

ey0019.2-11 | Neonatal diabetes mellitus | ESPEYB19

2.11. Cognitive deficits and impaired hippocampal long-term potentiation in KATP-induced DEND syndrome

S Yahil , DF Wozniak , Z Yan , S Mennerick , MS Remedi

Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2109721118. doi: 10.1073/pnas.2109721118. PMID: 34732576.Brief Summary: In a mouse model of KATP neonatal diabetes mellitus, this study examined the mechanisms of cognitive deficits and development delay observed in some patients with this form of diabetes. The cognitive deficits and development delay appeared to be independent of the diabetes per...

ey0017.11-11 | Body Weight Regulation and Insulin Sensitivity | ESPEYB17

11.11. Steroid metabolomic signature of insulin resistance in childhood obesity

AM Gawlik , M Shmoish , MF Hartmann , SA Wudy , Z Hochberg

To read the full abstract: Diabetes Care. 2020;43(2):405–410. doi: https://pubmed.ncbi.nlm.nih.gov/31727688/Here, Gawlik et al. describe the urinary steroid metabolomic profile associated with insulin resistance (IR) as assessed in a cohort of 87 non-syndromic obese children and adolescents.To explore the previously defined novel concept of a disease-spe...

ey0017.12-2 | Type 2 Diabetes | ESPEYB17

12.2. Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in hungary between 2001 and 2016 - a nationwide population-based study

L Barkai , Z Kiss , G, et al. Rokszin

To read the full abstract: Arch Med Sci. 2020;16(1):34–41. doi: 10.5114/aoms.2019.88406Short summary: Alarming numbers are reported here on the high prevalence of T2DM in children and adolescents in Hungary. In this nationwide population-based study, the prevalence of T2DM in children aged 0–18 years rose between 2001 and 2006 from 20/100 000 to 36/100 000 and decreased ...

ey0017.12-7 | Type 2 Diabetes | ESPEYB17

12.7. Dissecting racial bias in an algorithm used to manage the health of populations

Z Obermeyer , B Powers , C, et al. Vogeli

To read the full abstract: Science 2019;366(6464):447-53. doi: 10.1126/science.aax2342Short summary: Dissecting racial bias in health care systems revealed that a type of software program, which determines who receives access to high-risk health care management, routinely accepts healthier whites ahead of blacks who are less healthy.Comment: The yea...

ey0016.13-17 | Micronutrients | ESPEYB16

13.17. Improved micronutrient status and health outcomes in low- and middle-income countries following large-scale fortification: evidence from a systematic review and meta-analysis

EC Keats , LM Neufeld , GS Garrett , MNN Mbuya , Z Bhutta

Am J Clin Nutr. 2019 Jun 1;109(6):1696–1708. DOI: 10.1093/ajcn/nqz023• This systematic review and meta-analysis aimed to determine the impact of large-scale food fortification (LSFF) on health and nutrition outcomes in low- and middle-income countries (LMIC).• The authors demonstrate that LSFF increases serum micronutrient concentrations including iodine...

ey0020.14-4 | Section | ESPEYB20

14.4. Steroid metabolomic signature of insulin resistance in childhood obesity

AM Gawlik , M Shmoish , MF Hartmann , SA Wudy , Z Hochberg

Prof Hochberg was an exceptional paediatrician, endocrinologist and paediatric endocrinologist. He had an inquisitive mind, interest in various and wide fields, love for music, operas, books and people. Even in the field of endocrinology, he always researched beyond the visible. His groundbreaking contributions to the field of paediatric endocrinology have left an indelible mark on the medical community.Comment: To distinguish among chil...

ey0020.14-12 | Section | ESPEYB20

14.12. The effect of single-dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells

Z Hochberg , A Kuten , P Hertz , M Tatcher , A Kedar , A Benderly

Brief summary: this early experimental study analyzed the effects of radiation on growth hormone secretion and short-term cell survival in a cell culture model of dispersed rat anterior pituitary cells.At the time of this study, growth retardation had already been recognized as a significant adverse effect of brain irradiation in humans and experimental animals. Such growth retardation had been associated with impaired secretion of growth hormone in chil...

ey0021.8-2 | Other New Mechanisms | ESPEYB21

8.2. Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells

YC Lin , G Cheung , Z Zhang , V Papadopoulos

Brief Summary: This study investigated the synthesis pathway of pregnenolone (PREG) in the central nervous system. It identified the P450 enzyme CYP1B1 to be responsible for the production of PREG in human glial cells.Comment: Steroids have important functions in the central and peripheral nervous systems, including modulation of behavior, pain, stress and inflammation. Steroids in the brain can be produced de novo, as well as transported from p...

ey0021.13-18 | Identifying Health Disparities and Improving Access to Healthcare | ESPEYB21

13.18. Changing trends in the global, regional, and national burden of iodine deficiency among adolescents and young adults: population-based study

B Gong , C Wang , W Yang , Z Shan

Brief Summary: This prevalence study examined global, regional and national trends in iodine deficiency among adolescents and young adults, based on data from the Global Burden of Disease (GBD) 2019 database.Iodine deficiency is a significant public health concern as it can result in hypothyroidism, goiter, and alterations in growth and development. While universal salt iodination has had a significant impact, there is a need for better estimates of the ...

ey0016.1-10 | Updates on Kisspeptin | ESPEYB16

1.10. Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus

RSE Brown , Z Khant Aung , HR Phillipps , Z Barad , HJ Lein , U Boehm , RE Szawka , DR Grattan

To read the full abstract: Endocrinology 2019;160:1323–1332.Elevated prolactin levels suppress pulsatile release of GnRH from the hypothalamus, with a consequent reduction in pulsatile LH secretion from the pituitary. In this paper, the authors showed in mice that kisspeptin neurons located in the arcuate nucleus (ARC) respond to prolactin and conditional knockout of the prolactin r...