ISSN 1662-4009 (online)

ey0018.12-4 | Type 2 Diabetes | ESPEYB18

12.4. Multisite examination of depression screening scores and correlates among adolescents and young adults with type 2 diabetes

M Monaghan , CA Mara , JC Kichler , SC Westen , A Rawlinson , LM Jacobsen , RN Adams , JY Stone , KK Hood , SA Mulvaney

Can J Diabetes. 2021 Jan 22:S1499–2671(21)00018-6. doi: 10.1016/j.jcjd.2021.01.011. PMID: 33722492.In brief: The presence of depressive symptoms was assessed in 197 adolescents and young adults (ages 12 to 24 years) with T2DM. 19% reported elevated depressive symptoms and 19% admitted thoughts of self-harm. Older age, shorter diabetes duration, higher HbA1c level, being no...

ey0018.12-5 | Type 2 Diabetes | ESPEYB18

12.5. Cognitive function in adolescents and young adults with youth-onset type 1 versus type 2 diabetes: the search for diabetes in youth study

ALB Shapiro , D Dabelea , JM Stafford , R Jr D'Agostino , C Pihoker , AD Liese , AS Shah , A Bellatorre , JM Lawrence , L Henkin , S Saydah

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...

ey0018.12-6 | Type 2 Diabetes | ESPEYB18

12.6. Adolescent BMI and early-onset type 2 diabetes among Ethiopian immigrants and their descendants: a nationwide study

M Simchoni , U Hamiel , O Pinhas-Hamiel , I Zucker , T Cukierman-Yaffe , M Lutski , E Derazne , Z Beer , D Behar , L Keinan-Boker , O Mosenzon , D Tzur , A Afek , A Tirosh , I Raz , G Twig

Cardiovasc Diabetol. 2020 Oct 6;19(1):168. 10.1186/s12933-020-01143-z. PMID: 33023586.In brief: The impact of immigration on the risk of early-onset T2DM (before age 40 years) was assessed in a nationwide cohort. Data on 93 806 native Israelis and 27 684 Israelis of Ethiopian origin, assessed at a mean age 17.5 years, were linked to the Israeli National Diabetes Registry. After adjustment fo...

ey0018.12-7 | Type 2 Diabetes | ESPEYB18

12.7. The shared risk of diabetes between dog and cat owners and their pets: register based cohort study

RA Delicano , U Hammar , A Egenvall , C Westgarth , M Mubanga , L Byberg , T Fall , B Kennedy

BMJ. 2020 Dec 10;371:m4337. doi: 10.1136/bmj.m4337.In brief: Owners of dogs which have with diabetes are more likely to develop T2DM themselves than owners of dogs without diabetes. The underlying mechanisms might include shared diabetogenic health behaviours and environmental exposures. No shared risk of diabetes was found between cat owners and their cats.Co...

ey0018.12-8 | Metabolic Syndrome | ESPEYB18

12.8. COVID-19 and metabolic diseases: a heightened awareness of health inequities and a renewed focus for research priorities

WT Cefalu , GP Rodgers

Cell Metab. 2021 Mar 2;33(3):473–478. doi: 10.1016/j.cmet.2021.02.006. PMID: 33581046.In brief: This perspective paper discusses the observed disparities for metabolic diseases in regard to COVID-19. Disparities stem from systemic differences in access to care, environmental exposures and other sociodemographic factors.Comment: Hopefully, by...

ey0018.12-9 | Metabolic Syndrome | ESPEYB18

12.9. Sugar-Induced obesity and insulin resistance are uncoupled from shortened survival in drosophila

E Van Dam , LAG van Leeuwen , E Dos Santos , J James , L Best , C Lennicke , AJ Vincent , G Marinos , A Foley , M Buricova , JB Mokochinski , HB Kramer , W Lieb , M Laudes , A Franke , C Kaleta , HM Cocheme

Cell Metab. 2020; 31(4):710–725.e7. doi: 10.1016/j.cmet.2020.02.016. PMID: 32197072.In brief: High-sugar diets cause thirst, obesity and metabolic dysregulation, leading to insulin resistance, the MetS, T2DM and shortened lifespan. This study shows that high sugar diets induce dehydration in adult Drosophila. Water supplementation fully rescued the shortened lifespan, but ...

ey0018.12-10 | Metabolic Syndrome | ESPEYB18

12.10. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

LO Huang , A Rauch , E Mazzaferro , M Preuss , S Carobbio , CS Bayrak , N Chami , Z Wang , UM Schick , N Yang , Y Itan , A Vidal-Puig , M den Hoed , S Mandrup , TO Kilpelainen , RJF Loos

Nat Metab. 2021 Feb;3(2):228–243. doi: 10.1038/s42255-021-00346-2. PMID: 33619380.In brief: In this genome-wide association study, the authors were able to disentangle the mechanism that uncouples adiposity from its known cardiometabolic complications. They identified 62 genomic loci, at which the same allele is associated with both higher adiposity and lower cardiometabol...

ey0018.12-11 | Metabolic Syndrome | ESPEYB18

12.11. The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial

G Tsaban , A Yaskolka Meir , E Rinott , H Zelicha , A Kaplan , A Shalev , A Katz , A Rudich , A Tirosh , I Shelef , I Youngster , S Lebovitz , N Israeli , M Shabat , D Brikner , E Pupkin , M Stumvoll , J Thiery , U Ceglarek , JT Heiker , A Korner , K Landgraf , M von Bergen , M Bluher , MJ Stampfer , I Shai

Heart. 2020 Nov 23:heartjnl-2020-317802. doi: 10.1136/heartjnl-2020-317802. PMID: 33234670.In brief: This parallel-arm trial randomly assigned 294 adults with abdominal obesity/dyslipidemia to 1 of 3 dietary guidelines: healthy diet; Mediterranean diet; or ‘green Mediterranean’ diet. All groups received physical activity guidelines. Weight loss was higher in the two...

ey0018.12-12 | Metabolic Syndrome | ESPEYB18

12.12. Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity - a preview randomized clinical trial

E Dorenbos , M Drummen , T Adam , J Rijks , B Winkens , JA Martinez , S Navas-Carretero , G Stratton , N Swindell , P Stouthart , K Mackintosh , M Mcnarry , A Tremblay , M Fogelholm , A Raben , M Westerterp-Plantenga , A Vreugdenhil

Pediatr Obes. 2021 Jan;16(1):e12702. doi: 10.1111/ijpo.12702. PMID: 32681547.In brief: This randomized parallel trial, conducted in the Netherlands, the United Kingdom and Spain, assessed the impact of a high protein/low glycaemic diet vs. medium protein/medium glycaemic diet in reducing insulin resistance in 126 adolescents with overweight/obesity (mean age 13.6±2.2 years). At 2 ...

ey0018.12-13 | Lipids | ESPEYB18

12.13. Comparison of the mutation spectrum and association with pre and post treatment lipid measures of children with heterozygous familial hypercholesterolaemia (FH) from eight European countries

M Futema , U Ramaswami , L Tichy , MP Bogsrud , KB Holven , J Roeters van Lennep , A Wiegman , OS Descamps , A De Leener , E Fastre , M Vrablik , T Freiberger , H Esterbauer , H Dieplinger , S Greber-Platzer , AM Medeiros , M Bourbon , V Mollaki , E Drogari , SE Humphries

Atherosclerosis. 2021 Feb;319:108–117. doi: 10.1016/j.atherosclerosis.2021.01.008. PMID: 33508743.In brief: This multi-centre study included 2866 children with familial hypercholesterolemia (FH) from 8 European countries. The mutation spectrum was assessed, as were associations between gene mutations and clinical characteristics and pre and post-treatment lipid ...