ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Development 2018;145. pii:dev146829Branching morphogenesis is a key process during organogenesis of ductal and exocrine organs, e.g. lung, kidney, pancreas, and liver1. Regulatory components and local interactions for lung branching morphogenesis have been described in detail, mostly relying on receptor-ligand interactions between embryonic ...

To read the full abstract: J Adolesc Young Adult Oncol. 2017;6:294-298The difficulties in defining obesity in childhood cancer survivors have been emphasised. In these patients, body mass index (BMI) has been confirmed to be a poor predictor of body fatness, because of their impaired linear growth, body composition changes (decreased lean mass and fat redistribution) and abdominal adiposity. Th...

To read the full abstract: Dig Dis Sci. 2017;62:3110-3116This retrospective single-centre study is the first to report the impact of anti-tumor necrosis factor (anti-TNF) therapy on weight gain in children with inflammatory bowel disease (IBD). The results are consistent with data in adults, in whom weight gain during anti-TNF treatment was negatively correlated to pre-treatment BMI (1). A si...

To read the full abstract: Journal of Pediatrics 2018;192:105-114Rising degree of obesity has been shown to predict increased metabolic risk in obese children and adolescents (1). Nonetheless, it is unclear if BMI categories can be successfully applied to populations of obese children and adolescents for a risk-adapted stratification of therapeutic approaches, and here especially for the in...

To read the full abstract: NeuroImage 2017; 159: 236-247The results of this study suggest that, compared to adolescents with a low risk, lean adolescents with a high familial obesity risk show a weaker activation of neural systems subserving attentional self-regulation in response to food-denoting words. These same changes were found in overweight or obese adolescents. It is interestin...

To read the full abstract: Gastroenterology. 2017 Sep;153(3):711-722In adults, prebiotic intake is associated with improvements in satiety, postprandial glucose and insulin concentrations (1). The effect of prebiotic intervention in overweight/obese children has been rarely studied. This clinical trial showed that supplementation with oligofructose-enriched inulin for 16 weeks decreased BM...

To read the full abstract: Lancet 2018; 391(10133):1953-1964[Comment on 13.5, 13.6 & 13.7] Published just a week before the World Health Organization put out their first Essential Diagnostics List (http://www.who.int/medical_devices/diagnostics/WHO_EDL_2018.pdf), this series of 3 papers highlights the previo...

To read the full abstract: Lancet Diabetes Endocrinol 2018; 6:69-80The prevalence of T2DM in youth is increasing dramatically worldwide, but the bulk of the increase is expected to take place in Africa, South East Asia and South America. Although genetic factors may seem to be the obvious reason for such geographical differences, a careful analysis of the existing literature suggests that...

To read the full abstract: World J Diabetes 2017; 8(9):429-435This is the first paper to describe the clinical presentation and social determinants in youth with diabetes residing and cared for at a single tertiary care center in Ghana that is supported by the International Diabetes Federation’s Life for a Child (LFAC) program. As demonstrated by the ability to conduct and publish this stud...

To read the full abstract: Int J Endocrinol Metab 2017; 15(3):e55451Systematic neonatal screening for congenital hypothyroidism (CH) was first proposed by Dr Jean Dussault, a Canadian (adult) endocrinologist, in 1974. It was rapidly implemented in most high-income countries in the late 1970’s and 1980’s. Ideally, a screening program should be highly sensitive (able to ...