ISSN 1662-4009 (online)

ey0018.12-14 | Lipids | ESPEYB18

12.14. Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a mendelian randomization analysis using outcomes in first-degree relatives

Richardson Tom G , Wang Qin , Sanderson Eleanor , Mahajan Anubha , McCarthy Mark I , Frayling Timothy M , Ala-Korpela Mika , Sniderman Allan , Smith George Davey , Holmes Michael V

Lancet Healthy Longevity 2021 10.1016/S2666-7568(21)00086-6.In brief: Using a multivariable Mendelian randomization approach, genetic data on lipoprotein lipid levels and disease outcomes indicated that higher Apolipoprotein B (ApoB) levels increase the risks of coronary heart disease, stroke and T2DM, and shorten longevity. ApoB is emerging as a more sensitive measure of disease r...

ey0018.12-15 | Lipids | ESPEYB18

12.15. Detection of Lipoprotein X (LpX): A challenge in patients with severe hypercholesterolaemia

A Ćwiklińska , A Mickiewicz , R Kowalski , B Kortas-Stempak , A Kuchta , K Mucha , M Makowiecki , A Gliwińska , K Lewandowski , L Pęczek , M Fijałkowski , M Gruchała , M Jankowski

J Med Biochem. 2020 Sep 2;39(3):283–289. doi: 10.2478/jomb-2019-0038. PMID: 33269016.In brief: This case report serves as a platform to discuss the differential diagnosis of severe hypercholesterolemia. A young woman with T1DM and autoimmune liver disease presented with an LDL cholesterol value >1000 mg/dl (>26 mmol/l). She had no family history to suggest familial hyp...

ey0018.12-16 | Lipids | ESPEYB18

12.16. A multidimensional precision medicine approach identifies an autism subtype characterized by dyslipidemia

Y Luo , A Eran , N Palmer , P Avillach , A Levy-Moonshine , P Szolovits , IS Kohane

Nat Med. 2020 Sep;26(9):1375–1379. doi: 10.1038/s41591-020-1007-0. PMID: 32778826.In brief: A subtype of autism arising from a cluster of genes that regulate both cholesterol metabolism and brain development was identified by integrating multiple data modalities.Comment: Autism spectrum disorder (ASD) is now estimated to affect 1:54 children ...

ey0018.13 | Jean-Pierre Chanoine | ESPEYB18

13. Global Health for the Paediatric Endocrinologist

Chanoine Jean-Pierre

PrefaceWelcome to the 6th edition of this chapter on Global Health in Pediatric Endocrinology and Diabetes. As usual, the selected articles cover many aspects of our specialty. This year is important because we celebrate the 100th anniversary of the discovery of insulin by Sir Frederick Banting, Charles Best, John Macleod and James Collip at the University of Toronto in 1921. This discovery paved the way for the first administration...

ey0018.13-1 | History and Society | ESPEYB18

13.1. Population history and ecology, in addition to climate, influence human stature and body proportions

E Pomeroy , JT Stock , JCK Wells

Sci Rep 2021; 11:274. doi: 10.1038/s41598-020-79501-w– Variation in human stature and limb proportions reflects not only thermal adaptation but also environmental stressors– The authors analysed global variation in stature and limb length using published anthropometric data from adult male and female populations across the world in relation to climate and net primary productiv...

ey0018.13-2 | Diabetes | ESPEYB18

13.2. Worldwide differences in childhood type 1 diabetes: The SWEET experience

M Saiyed , D Hasnani , GT Alonso , E Richmond , S Besancon , A Cotterill , U Ngwu , C Mazza , D Rottenbourg , S Lanzinger

Pediatr Diabetes 2020;1–8. doi: 10.1111/pedi.13137– As part of the SWEET initiative, the authors analyzed the clinical characteristics of 26,726 individuals with type 1 diabetes (T1D) aged < 21 years living in Europe, Asia/Middle East/Africa, Australia/New Zealand, North America and South America– Among patient care indicators, the percent of HbA1c < 7.5% ranged between r...

ey0018.13-3 | Diabetes | ESPEYB18

13.3. Rapid increases in observed incidence and prevalence of Type 1 diabetes in children and youth in Mali, 2007-2016

JL Sandy , S Besancon , AT Sidibe , M Minkailou , A Togo , GD Ogle

Pediatr Diabetes. 2021;1–7. doi: 10.1111/pedi.13191– The development of an awareness campaign and of a prospective registry in Mali enabled the collection of more accurate data on the incidence, prevalence and mortality of Type 1 diabetes (T1D) in children and youth <25 years– T1D incidence rose from 0.12 in 2007 to 0.74 in 2016 and T1D prevalence from 0.43 in 2007 to 2.90 in...

ey0018.13-4 | Diabetes | ESPEYB18

13.4. Heat-stability study of various insulin types in tropical temperature conditions: New insights towards improving diabetes care

B Kaufmann , P Boulle , F Berthou , M Fournier , D Beran , I Ciglenecki , M Townsend , G Schmidt , M Shah , S Cristofani , P Cavailler , M Foti , L Scapozza

PLoS ONE 2021;16: e0245372. doi: 10.1371/journal.pone.0245372– According to pharmacopeia, unopened insulin vials must be stored in a refrigerator (2–8 °C) while storage at ambient temperature (25–28 °C) is usually permitted for the 4-week usage period during treatment– The authors investigated whether insulin remains stable and retains biological activity...

ey0018.13-5 | Diabetes | ESPEYB18

13.5. Access to insulin delivery devices and glycated haemoglobin in lower-income countries

EL Klatman , GD Ogle

World J Diabetes 2020; 11: 358–369. https://dx.doi.org/10.4239/wjd.v11.i8.358– To assess access to insulin delivery devices and HbA1c in 41 countries supported by the Life for a Child (LFAC) program– Syringes (83.1%), insulin pens (16.7%) and pumps (0.2%) were used for insulin delivery– If supplies were not donated, there was variable access to HbA1c testing within publi...

ey0018.13-6 | Endocrinology | ESPEYB18

13.6. Tiered healthcare in South Africa exposes deficiencies in management and more patients with infectious etiology of primary adrenal insufficiency

TRP Mofokeng , KCZ Ndlovu , SA Beshyah , IL Ross

PLoS ONE 2020; 15: e0241845. doi: 10.1371/journal.pone.0241845– To determine the etiology, presentation, and available management strategies for primary adrenal insufficiency in South Africa– A 23-question survey was sent to 23,321 physicians. It covered several domains including patient demographics, etiology, presentation, therapy, and barriers to diagnosis and treatment,&...