ESPE Yearbook of Paediatric Endocrinology

Pediatrics. 2021 Mar 22:e2020023549. doi: 10.1542/peds.2020-023549. PMID: 33753543.This retrospective, single center chart review study assessed the incidence of arterial or venous thrombosis during gender affirming hormone therapy (GAHT) in 611 transgender adolescents. The prevalence of thrombosis risk factors was also investigated. No increased risk of thrombosis was found over a short ...

J Bone Miner Res. 2021 May;36(5):931–941. doi: 10.1002/jbmr.4262. PMID: 33507568.This restrospective study of the Cohort of Gender Dysphoria investigated bone geometry parameters of 106 adolescent trans-women and 216 adolescent trans-men during early and late start of gonadotropin-releasing hormone agonist (GnRHa) and gender affirming hormone therapy (GAHT). Transgender youth who started tr...

JAMA Netw Open. 2020;3(10):e2015665. 10.1001/jamanetworkopen.2020.15665.. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2771377In brief: This Danish population-based 20-year cohort study provides strong epidemiological data supporting substantial increases in central precocious pub...

Hum Reprod. 2021 Jun 18;36(7):1959–1969. 10.1093/humrep/deab039 https://academic.oup.com/humrep/article-abstract/36/7/1959/6179308?redirectedFrom=fulltextIn brief: This large prospective population-based pregnancy cohort study identifies an association between maternal stressful li...

J Clin Endocrinol Metab. 2020; 105(9): 3103–3107.https://pubmed.ncbi.nlm.nih.gov/32629476/In this narrative review, the authors discuss the potential role of novel regenerative therapies for the treatment of adrenal insufficiency, including gene therapy and cell replacement strategies. More specifically, the authors discuss the heterogeneity in adrenal function in patients with Addison...

Pediatr Blood Cancer. 2021; 68: e28894. https://pubmed.ncbi.nlm.nih.gov/33459500/This cross-sectional observational study examined reproductive function in a nationwide cohort of female childhood acute lymphoblastic leukemia (ALL) survivors.Self-reported reproductive characteristics (age at menarche, virginity status, desire for children, pregnancy rates, and adverse ...

Cancer. 2021; 127: 1439–1447. https://pubmed.ncbi.nlm.nih.gov/33491215/This nationwide, Finnish registry-based study identified a lower likelihood of primary pregnancy (relative risk =0.72; 95% CI, 0.64–0.80) in 1357 childhood cancer survivors (CCS) diagnosed in 1971-2012 and 6658 age-matched general population controls. However the risk of induced abortion was similar in both gro...

Pediatr Blood Cancer. 2020; 67: e28617. https://pubmed.ncbi.nlm.nih.gov/32715632/This retrospective single-centre study aimed to develop a final height prediction model based on data from 212 long-term survivors (aged 5-20.4 years) of childhood central nervous system (CNS) tumors who received craniospinal irradiation (CSI) and with a median follow up of 10.2 years. Mean fin...

J Clin Endocrinol Metab. 2020; 105: e3730–41. https://pubmed.ncbi.nlm.nih.gov/32706856/This retrospective analysis of the Pfizer International Growth Database (KIGS) included 1149 cancer survivors with growth hormone deficiency (GHD) who had received growth hormone therapy (GHT) for at least 5 years. Patients with craniopharyngioma had the best 5-year growth response ...

J Pediatr Endocrinol Metab. 2020; 33: 1257–1263. https://pubmed.ncbi.nlm.nih.gov/32845867/This retrospective study evaluated the prevalence of adrenal insufficiency after a single intra-articular corticosteroid injection (IACI) in 60 children with chronic arthritis. Adrenal insufficiency was diagnosed in 30% (18/60) and was associated with higher doses of injected corticosteroid. Media...