ISSN 1662-4009 (online)

ey0018.14-10 | (1) | ESPEYB18

14.10. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

Choi Sekyu , Zhang Bing , Ma Sai , Gonzalez-Celeiro Meryem , Stein Daniel , Jin Xin , Kim Seung Tea , Kang Yuan-Lin , Besnard Antoine , Rezza Amelie , Grisanti Laura , Buenrostro Jason D , Rendl Michael , Nahrendorf Matthias , Sahay Amar , Hsu Ya-Chieh

Nature 2021; 592: 428–432https://www.nature.com/articles/s41586-021-03417-2These authors report that in mice the stress hormone corticosterone (the rodent equivalent of cortisol in humans) acts on dermal papillae to suppress expression of Gas6 (encoding growth arrest specific 6) and thereby cause hair follicle stem cell (HFSC) quiescence and reduced hair growth. They show that...

ey0018.14-11 | (1) | ESPEYB18

14.11. Ageing hallmarks exhibit organ-specific temporal signatures

Schaum Nicholas , Lehallier Benoit , Hahn Oliver , Palovics Robert , Hosseinzadeh Shayan , Lee Song E , Sit Rene , Lee Davis P , Losada Patricia Moran , Zardeneta Macy E , Fehlmann Tobias , Webber James T , McGeever Aaron , Calcuttawala Kruti , Zhang Hui , Berdnik Daniela , Mathur Vidhu , Tan Weilun , Zee Alexander , Tan Michelle , The Tabula Muris Consortium , Pisco Angela Oliveira , Karkanias Jim , Neff Norma F , Keller Andreas , Darmanis Spyros , Quake Stephen R , Wyss-Coray Tony

Nature 2020; 583: 596–602https://www.nature.com/articles/s41586-020-2499-yIn order to understand the cellular processes that underlie ageing, the authors performed plasma proteomics at 10 different ages across the lifespan of the mouse. They integrated these data with a parallel large study published alongside this paper in the same edition (1), which describes the ‘Mouse ...

ey0018.14-12 | (1) | ESPEYB18

14.12. Associations between maternal antenatal corticosteroid treatment and mental and behavioral disorders in children

Raikkonen Katri , Gissler Mika , Kajantie Eero

JAMA. 2020; 323(19): 1924-1933. https://jamanetwork.com/journals/jama/fullarticle/2766162The authors assembled a retrospective population-based cohort using nationwide registries of births and public specialized medical care settings in Finland in order to study whether antenatal corticosteroid treatment is associated with mental and behavioral disorders in children. Antenat...

ey0018.14-13 | (1) | ESPEYB18

14.13. Past extinctions of homo species coincided with increased vulnerability to climatic change

Raia Pasquale , Mondanaro Alessandro , Melchionna Marina , Di Febbraro Mirko , Diniz-Filho Jose A F , Rangel Thiago F , Holden Philip B , Carotenuto Francesco , Edwards Neil R , Lima-Ribeiro Matheus S , Profico Antonio , Maiorano Luigi , Castiglione Silvia , Serio Carmela , Rook Lorenzo

One Earth, Volume 3, Issue 4, 23 October 2020, Pages 480-490 https://bit.ly/3vFcRueBy integrating past climate and fossil databases, these authors suggest that climate change was the primary factor in the extinction of Homo species.Homo erectus, H. heidelbergensis and H. neanderthalensis all became extinct. Why? And are we going that way too? The authors claim that cli...

ey0018.14-14 | (1) | ESPEYB18

14.14. The impact of sex on gene expression across human tissues

Oliva Meritxell , Munoz-Aguirre Manuel , Kim-Hellmuth Sarah , Wucher Valentin , Gewirtz Ariel DH , Cotter Daniel J , Parsana Princy , Kasela Silva , Balliu Brunilda , Vinuela Ana , Castel Stephane E , Mohammadi Pejman , Aguet Francois , Zou Yuxin , Khramtsova Ekaterina A , Skol Andrew D , Garrido-Martin Diego , Reverter Ferran , Brown Andrew , Evans Patrick , Gamazon Eric R , Payne Anthony , Bonazzola Rodrigo , Barbeira Alvaro N , Hamel Andrew R , Martinez-Perez Angel , Soria Jose Manuel , GTEx Consortium , Pierce Brandon L , Stephens Matthew , Eskin Eleazar , Dermitzakis Emmanouil T , Segre Ayellet V , Im Hae Kyung , Engelhardt Barbara E , Ardlie Kristin G , Montgomery Stephen B , Battle Alexis J , Lappalainen Tuuli , Guigo Roderic , Stranger Barbara E

Science 2020 Sep; 369(6509): eaba3066https://bit.ly/3wMzM8xBy integrating sex-specific Genotype-Tissue Expression (GTEx) data with gene function and transcription factor binding annotations, these authors describe mechanisms contributing to sex differences in the human transcriptome.Many complex human traits and diseases exhibit sex-specific characteristics. These sex differences have b...

ey0018.15-1 | (1) | ESPEYB18

15.1. Analysis of overlapping genetic association in type 1 and type 2 diabetes

Inshaw Jamie RJ , Sidore Carlo , Cucca Francesco , Stefana M Irina , Crouch Daniel JM , McCarthy Mark I , Mahajan Anubha , Todd John A

Diabetologia. 2021 Jun;64(6):1342–1347. 10.1007/s00125-021-05428-0. https://pubmed.ncbi.nlm.nih.gov/33830302/By studying data from very large-scale genome-wide association studies (GWAS) in European ancestry individuals, the authors compared genetic signals that confer risk of type 1 (T1DM) and type 2 diabetes (T2DM). Only 5 signals ...

ey0018.15-2 | (1) | ESPEYB18

15.2. Interpreting type 1 diabetes risk with genetics and single-cell epigenomics

Chiou Joshua , Geusz Ryan J , Okino Mei-Lin , Han Jee Yun , Miller Michael , Melton Rebecca , Beebe Elisha , Benaglio Paola , Huang Serina , Korgaonkar Katha , Heller Sandra , Kleger Alexander , Preissl Sebastian , Gorkin David U , Sander Maike , Gaulton Kyle J

Nature. 2021 volume 594, 398–402https://www.nature.com/articles/s41586-021-03552-wThe authors report a large genome-wide association study (GWAS) of type 1 diabetes (T1D) in 18 942 cases and 501 638 controls, finding 92 T1D-associated genomic loci (59 known and 33 novel). Furthermore they analyse DNA chromatin patterns in pancreas and peripheral white blood cells to help ident...

ey0018.15-3 | (1) | ESPEYB18

15.3. Metabolic effects of late dinner in healthy volunteers - a randomized crossover clinical trial

Gu Chenjuan , Brereton Nga , Schweitzer Amy , Cotter Matthew , Duan Daisy , Borsheim Elisabet , Wolfe Robert R , Pham Luu V , Polotsky Vsevolod Y , Jun Jonathan C

Journal of Clinical Endocrinology & Metabolism, 2020. Vol 105(8), 2789–2802. doi: https://doi.org/10.1210/clinem/dgaa354The authors performed a randomized crossover trial of Late Dinner (22:00 hours) vs Routine Dinner (18:00) in a laboratory setting in 20 healthy adult volunteers. Meal contents and sleep period (23:00-07:00) were kept the same in both arms and sleep patterns were u...

ey0018.15-4 | (1) | ESPEYB18

15.4. Ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes during the COVID-19 pandemic in Germany

Kamrath Clemens , Monkemoller Kirsten , Biester Torben , Rohrer Tilman R , Warncke Katharina , Hammersen Johanna , Holl Reinhard W

JAMA. 2020;324(8):801–804.https://jamanetwork.com/journals/jama/fullarticle/2768716The authors analysed data from the German Diabetes Prospective Follow-up Registry (DPV) of children and adolescents with Type 1 diabetes (T1D) between March 13 to May 13, 2020, when most kindergartens and schools in Germany were closed due to COVID-19 restrictions. Compared to the previou...