ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 24 of about 502 results

ey0018.5-13 | Advances in skeletal biology | ESPEYB18

5.13. SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

A Haseeb , KC Ranjan , M Angelozzij , C de Charleroy , D Rux , RJ Tower , L Yao , R Pellegrino da Silva , M Pacifici , L Qin , V Lefebvre

Proc Natl Acad Sci USA 2021 Feb 23;118(8):e2019152118. Abstract: https://pubmed.ncbi.nlm.nih.gov/33597301/In brief: Sox9 is the key transcription factor and master regulator of chondrocyte differentiation during skeletal development. This paper demonstrates that SOX9 also has a key role during postnatal life to maintain open growth plates and healthy articular cartilage by preventi...
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ey0018.6-9 | Patient Related Outcomes | ESPEYB18

6.9. Early Genital Surgery in Disorders/Differences of Sex Development: Patients' Perspectives

E Bennecke , S Bernstein , P Lee , TC van de Grift , A Nordenskjold , M Rapp , M Simmonds , JC Streuli , U Thyen , C Wiesemann

Arch Sex Behav. 2021 Apr;50(3):913–923. doi: 10.1007/s10508-021-01953-6. PMID: 33712989This paper describes a patient cohort study of 459 individuals with various DSD diagnoses, as part of the dsd-LIFE study. Patients were included at 14 different sites in 6 European countries.Genital surgery has been increasingly questioned in the past decade. Both the timin...
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ey0018.7-6 | Clinical Guidance | ESPEYB18

7.6. GnRH stimulation testing and serum inhibin B in males: insufficient specificity for discriminating between congenital hypogonadotropic hypogonadism from constitutional delay of growth and puberty

H Mosbah , C Bouvattier , L Maione , S Trabado , G De Filippo , A Cartes , A Donzeau , P Chanson , S Brailly-Tabard , AA Dwyer , R Coutant , J Young

Hum Reprod. 2020 Oct 1;35(10):2312–2322. 10.1093/humrep/deaa185. PMID: 32862222. https://academic.oup.com/humrep/article/35/10/2312/5899242In brief: This study shows that both the GnRH stimulation test and serum inhibin B have insufficient specificity to discriminate congenital hypogonadotropic hypogonadism (CHH) from c...
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ey0018.8-14 | New Paradigms | ESPEYB18

8.14. DNA Methylation of steroidogenic enzymes in benign adrenocortical tumors: New insights in aldosterone-producing Adenomas

G Di Dalmazi , L Morandi , B Rubin , C Pilon , S Asioli , V Vicennati , A De Leo , F Ambrosi , D Santini , U Pagotto , V Maffeis , A Fassina , F Fallo

J Clin Endocrinol Metab. 2020 Dec 1;105(12): dgaa585.https://pubmed.ncbi.nlm.nih.gov/32844182/The aim of this histological study was to investigate DNA methylation and expression of genes encoding steroidogenic enzymes in benign adrenocortical tumors. The findings suggest that DNA methylation plays a regulatory role in CYP11B2 expression and may contribute to aldosterone hypersecretion in a...
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ey0018.10-1 | (1) | ESPEYB18

10.1. Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany?

SR Tittel , J Rosenbauer , C Kamrath , J Ziegler , F Reschke , J Hammersen , K Monkemoller , A Pappa , T Kapellen , RW Holl , Initiative DPV

Diabetes Care. 2020;43(11):e172–e173. doi: 10.2337/dc20-1633During the first phase of the COVID-19 pandemic, the DPV (the German diabetes registry database) study group asked whether or not the COVID-19 lockdown had affected the incidence of pediatric T1D in Germany (1). More than 210 German pediatric diabetes centers contributed their data on pediatric patients with T1D with an onset at ag...
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ey0018.11-14 | New insight into preconceptional and prenatal programming | ESPEYB18

11.14. Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring

J Jonsson , KM Renault , S Garcia-Calzon , A Perfilyev , AC Estampador , K Norgaard , M Vendelbo Lind , A Vaag , L Hjort , KF Michaelsen , E Malchau Carlsen , PW Franks , C Ling

Diabetes 2021 Apr;70(4):854–866. https://pubmed.ncbi.nlm.nih.gov/33431374/These authors performed a randomized trial of obese pregnant women (n=425) to investigate the effects of a pregnancy lifestyle intervention on epigenetic variations in umbilical cord blood, on neonatal body composition (DXA) and on offspring BMI in later life (up to 3 years). Offspring of mothers who re...
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ey0018.12-5 | Type 2 Diabetes | ESPEYB18

12.5. Cognitive function in adolescents and young adults with youth-onset type 1 versus type 2 diabetes: the search for diabetes in youth study

ALB Shapiro , D Dabelea , JM Stafford , R Jr D'Agostino , C Pihoker , AD Liese , AS Shah , A Bellatorre , JM Lawrence , L Henkin , S Saydah

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...
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ey0018.13-7 | Endocrinology | ESPEYB18

13.7. We all have a role to play: redressing inequities for children living with CAH and other chronic health conditions of childhood in resource-poor settings

K Armstrong , AB Yap , S Chan-Cua , ME Craig , C Cole , V Chi Dung , J Hansen , M Ibrahim , H Nadeem , A Pulungan , J Raza , A Utari , P. Ward

Int. J. Neonatal Screen 2020; 6: 76. doi: 10.3390/ijns6040076– CLAN (Caring and Living as Neighbours) is an Australian non-governmental organisation (NGO) committed to a rights-based approach to optimizing quality of life for children and young people living with CAH and other chronic health conditions in resource-limited settings– This paper used exploratory case study as a method t...
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ey0018.15-3 | (1) | ESPEYB18

15.3. Metabolic effects of late dinner in healthy volunteers - a randomized crossover clinical trial

Gu Chenjuan , Brereton Nga , Schweitzer Amy , Cotter Matthew , Duan Daisy , Borsheim Elisabet , Wolfe Robert R , Pham Luu V , Polotsky Vsevolod Y , Jun Jonathan C

Journal of Clinical Endocrinology & Metabolism, 2020. Vol 105(8), 2789–2802. doi: https://doi.org/10.1210/clinem/dgaa354The authors performed a randomized crossover trial of Late Dinner (22:00 hours) vs Routine Dinner (18:00) in a laboratory setting in 20 healthy adult volunteers. Meal contents and sleep period (23:00-07:00) were kept the same in both arms and sleep patterns were u...
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ey0019.1-13 | Clinical Papers | ESPEYB19

1.13. Management of children and young people with idiopathic pituitary stalk thickening, central diabetes insipidus, or both: a national clinical practice consensus guideline.

M Cerbone , J Visser , C Bulwer , A Ederies , K Vallabhaneni , S Ball , I Kamaly-Asl , A Grossman , H Gleeson , M Korbonits , V Nanduri , V Tziaferi , T Jacques , HA Spoudeas

Lancet Child Adolesc Health. 2021 Sep;5(9):662-676. doi: 10.1016/S2352-4642(21)00088-2. Epub 2021 Jun 30; PMID: 34214482.Brief Summary: This comprehensive guideline defines the role of cerebrospinal fluid tumor markers, whole-body imaging, and the indications, timing and risks of stalk biopsy, as well as criteria for discharge in children and young people with idiopathic pituitary stalk...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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