ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Lancet 2017; 390: 374-88See comment on 13.4...

To read the full abstract: Lancet 2017; 390(10092): 389-398[Comment on 13.3 & 13.4] Access to quality medical care is often difficult in resource-limited settings and depends upon the collaboration of key stakeholder groups, including global/regional health policymakers, national governments and health system managers, the pharmaceutical industry and trained clinicians and health work...

To read the full abstract: J Public Health (Oxf) 2017:1-9Our efforts to control overweight and obesity in children are severely hampered because most of their parents (and indeed most of their health professionals!) cannot visually recognise an obese child, let alone one who is overweight. This is particularly difficult at around the ages 4-6 years old because this coincides with the BMI n...

To read the full abstract: N Engl J Med 2017;377:13-27Other estimates of the global trends and projections in obesity have been published. In this regard, the current analysis provides similar, albeit equally worrying, data on the trends towards more obesity across all regions of the world. Moreover, a particular advance of this current study, which was funded by the Bill and Melind...

Brief summary: This randomized, double-blind, phase 3 trial of youths with inadequately controlled T2D, dulaglutide treatment was superior to placebo in reducing the glycated hemoglobin level at 26 weeks.Comment: T2D in children and adolescents is an aggressive disease with early onset of complications, leading to significant morbidity and mortality. After three decades with no efficient treatment, there is finally light at the end of the tunnel.<p c...

Brief summary: The potency of insulin decreases with increasing temperatures. This pilot study compared the concentration and structure of commonly used types of insulin when exposed to high temperatures for prolonged periods of time.Manufacturers are required to provide information on how insulin vials and cartridges should be kept by the patient. These recommendations assume that a working fridge is available and that the medicine can be protected from...

Brief summary: This study describes the genetic and clinical characteristics of 3βHSD2 deficiency in children seen at a single center in Algeria. It describes clinical outcomes, including the frequency of adrenal rest tumors in this population.3β-hydroxysteroid dehydrogenase 2 deficiency (3βHSD2) is a rare form of congenital adrenal hyperplasia. This mixed longitudinal and cross-sectional study was performed in a single Algerian center bet...

Brief Summary: This multicentre retrospective cross-sectional study provides critical insights into the epidemiology, clinical presentation, and neurodevelopmental outcomes of central congenital hypothyroidism (CCH).CCH is a rare disorder that occurs due to insufficient hypothalamic-pituitary stimulation of the thyroid, characterized by low total T4 (TT4) with either low, normal or slightly elevated TSH. Most newborn screening (NBS) programs for CH are p...

Brief Summary: This longitudinal study provides an in-depth analysis of the clinical, endocrine, and testicular ultrasound (US) patterns in Klinefelter Syndrome (KS) from infancy through puberty and into adulthood, highlighting the progression of testicular degeneration in these patients.In this study, 155 KS patients with the classical 47,XXY karyotype, aged 7 months to 55 years, were prospectively evaluated at a single referral center following a stand...

Brief Summary: For both clinicians and patients, it is of great interest to have easily-applicable predictors to forecast weight reductions achievable by lifestyle intervention (LI). This study identified 3 distinct clusters of responses to paediatric outpatient LI. Up to 2 years after LI initiation, responses ranged from ‘pronounced BMIz loss’ (in 19% of patients; median delta-BMIz: -0.61 (IQR: -0.76 to -0.49) to ‘moderate BMIz loss’ (in 45%; -0.23 (-0.33 ...