ISSN 1662-4009 (online)

ey0015.12-12 | Review of the year | ESPEYB15

12.12 Effects of superfoods on risk factors of metabolic syndrome: a systematic review of human intervention trials

JJ van den Driessche , J Plat , RP Mensink

To read the full abstract: Food & Function 2018;9:1944-1966"Functional foods" are foods that have a potentially positive effect on health beyond basic nutrition. Oatmeal is a familiar example of a functional food as it contains soluble fiber that can lower cholesterol levels. Foods are often modified to have health benefits, for example fortified orange juice with calcium to improve bone health....

ey0020.5-3 | Clinical Guidance and Studies | ESPEYB20

5.3. Pre-pubertal accelerometer-assessed physical activity and timing of puberty in British boys and girls: the Millennium Cohort Study

TS Cheng , S Brage , EMF van Sluijs , KK Ong

Brief summary: This longitudinal UK cohort study examined the prospective associations between objectively measured physical activity, independently of BMI, and pubertal timing in boys and girls.This large study analyzed device-measured physical activity and its intensity in relation to puberty timing, using accelerometers worn on the right hip. A previous meta-analysis reported that female athletes had later age at menarche than non-athletes (1), but it...

ey0020.7-8 | Bone Health in Childhood Cancer Survivors | ESPEYB20

7.8. Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study

JE van Atteveld , DTC de Winter , VG Pluimakers , M Fiocco , RAJ Nievelstein , MGG Hobbelink , ACH de Vries , JJ Loonen , E van Dulmen-den Broeder , HJ van der Pal , SMF Pluijm , LCM Kremer , CM Ronckers , M van der Heiden-van der Loo , AB Versluijs , M Louwerens , D Bresters , HM van Santen , DS Olsson , I Hoefer , SAA van den Berg , J den Hartogh , WJE Tissing , SJCMM Neggers , MM van den Heuvel-Eibrink , Dutch LATER study group

Brief summary: This Dutch cross-sectional study aimed to assess risk factors for impaired bone mineral density (BMD) and fractures (particularly vertebral fractures) in adult survivors of childhood cancer. The relationships between low BMD (Z-score ≤–1), very low BMD (Z-score ≤–2), fractures, vertebral fractures, and demographic, treatment-related, endocrine, and lifestyle-related factors was analyzed by logistic regression.<p class=...

ey0020.7-15 | Long-Term Surveillance for Endocrine Complications in Childhood Cancer Survivors | ESPEYB20

7.15. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study

JE van Atteveld , DTC de Winter , VG Pluimakers , M Fiocco , RAJ Nievelstein , MGG Hobbelink , LCM Kremer , MA Grootenhuis , H Maurice-Stam , WJE Tissing , ACH de Vries , JJ Loonen , E van Dulmen-den Broeder , HJH van der Pal , SMF Pluijm , M van der Heiden-van der Loo , AB Versluijs , M Louwerens , D Bresters , HM van Santen , I Hoefer , SAA van den Berg , J den Hartogh , JHJ Hoeijmakers , SJCMM Neggers , MM van den Heuvel-Eibrink , Dutch LATER study group

Brief summary: This cross-sectional study explored the risk factors for pre-frailty, frailty, and sarcopenia in a cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001.Frailty was defined as the presence of at least two (pre-frailty) or three (frailty) of the following criteria: low appendicular lean mass (low percentage of lean tissue in the limbs assessed by dual-energy X-ray absorptiometry, DXA), low muscle strength (measured with...

ey0021.9-6 | Fertility Issues | ESPEYB21

9.6. Reproductive outcomes and reproductive health care utilization among male survivors of childhood cancer: a DCCSS-LATER study

JJM Claessens , A Penson , EM Bronkhorst , LCM Kremer , E van Broeder 7 , Heiden-van der Loo M van der , WJE Tissing , Pal HJH van der , NMA Blijlevens , Heuvel-Eibrink MM van den , AB Versluys , D Bresters , CM Ronckers , I Walraven , CCM Beerendonk , JJ Loonen , group. Dutch later study

Brief Summary: The nationwide Dutch Childhood Cancer Survivor (CCS) LATER cohort study assessed by questionnaire the reproductive outcomes and reproductive health care in 1317 male CCS and 407 male siblings. This included 491 CCS and 185 siblings who expressed a previous or current desire for children. Fewer CCS than siblings reported having biological children (65% vs. 88%). The type of conception was similar between CCSs and siblings (spontaneous conception in 90% of both gr...

ey0018.9-8 | Genetic susceptibility to treatment-related gonadotoxicity | ESPEYB18

9.8. Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function

ALF van der Kooi , M van Dijk , L Broer , MH van den Berg , JSE Laven , FE van Leeuwen , CB Lambalk , A Overbeek , JJ Loonen , HJ van der Pal , WJ Tissing , B Versluys , D Bresters , CCM Beerendonk , CR Ronckers , M van der Heiden-van der Loo , GL Kaspers , ACH de Vries , LL Robison , MM Hudson , W Chemaitilly , J Byrne , C Berger , E Clemens , U Dirksen , J Falck Winther , SD Fossa , D Grabow , R Haupt , M Kaiser , T Kepak , J Kruseova , D Modan-Moses , SMF Pluijm , C Spix , O Zolk , P Kaatsch , JH Krijthe , LC Kremer , Y Yasui , RJ Brooke , AG Uitterlinden , M van den Heuvel-Eibrink , E Mvan Dulmen-den Broeder

Hum Reprod. 2021; 36: 1120–1133. https://pubmed.ncbi.nlm.nih.gov/33582778/This multi-centre retrospective cohort study identifies that common genetic variants in DNA repair genes modify the damage induced by alkylating agents on ovarian function, as assessed by low AMH levels.Alkylating agents are known to induce apoptosis of cancer cells by damaging DNA replicat...

ey0019.9-14 | Fertility issues and reproductive outcomes in childhood cancer survivors | ESPEYB19

9.14. Effect of Genetic Variation in CYP450 on gonadal impairment in a European cohort of female childhood cancer survivors, based on a candidate gene approach: results from the PanCareLIFE study

der Perk MEM van , L Broer , Y Yasui , LL Robison , MM Hudson , JSE Laven , der Pal HJ van , WJE Tissing , B Versluys , D Bresters , GJL Kaspers , Vries ACH de , CB Lambalk , A Overbeek , JJ Loonen , CCM Beerendonk , J Byrne , C Berger , E Clemens , U Dirksen , Winther J Falck , SD Fossa , D Grabow , M Muraca , M Kaiser , T Kepak , J Kruseova , D Modan-Moses , C Spix , O Zolk , P Kaatsch , JH Krijthe , LCM Kremer , RJ Brooke , JL Baedke , RHN van Schaik , JN van den Anker , AG Uitterlinden , AME Bos , FE van Leeuwen , E van Dulmen-den Broeder , ALF van der Kooi , MM van den Heuvel-Eibrink

On Behalf Of The PanCareLIFE Consortium. m.e.m.vanderperk@prinsesmaximacentrum.nl Cancers (Basel). 2021; 13: 4598. PMID: 34572825.Brief Summary: This cohort study of female childhood cancer survivors (CCS) identified associations between specific nucleotide polymorphisms (SNP) in cytochrome P450 (CYP450) enzymes, which metabolize alkylating agents (AA), and variability in AA-induced o...

ey0017.9-1 | Fertility-Related Issues | ESPEYB17

9.1. Anti-Mullerian hormone and Inhibin B after stem cell transplant in childhood: A comparison of myeloablative, reduced intensity and treosulfan-based chemotherapy regimens

A Leiper , M Houwing , EG Davies , K Rao , S Burns , E Morris , J Laven , AL van der Kooi , M van den Heuvel Eibrink , S Nussey

To read the full abstract: Bone Marrow Transplant. 2020 Apr 24. doi: 10.1038/s41409-020-0914-5. Epub ahead of print. a.leiper@nhs.netAnti-Müllerian hormone (AMH), secreted by granulosa cells of growing pre- and early antral ovarian follicles, reflects the reserve of primordial ovarian follicles at any time from birth to menopause. Serum AMH leve...

ey0016.15-14 | (1) | ESPEYB16

15.14. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

Beumer Joep , Artegiani Benedetta , Post Yorick , Reimann Frank , Gribble Fiona , Nguyen Thuc Nghi , Zeng Hongkui , Van den Born Maaike , Van Es Johan H , Clevers Hans

To read the full abstract: Nature Cell Biology 20,909–916 (2018)Produced by scattered Enteroendocrine cells (EECs)found along the length of the intestinal epithelium, gut hormones generate signals related to the rate of nutrient absorption, the composition of the luminal milieu and the integrity of the epithelial barrier. To study these rare cells, these authors combined the te...

ey0015.3-17 | Reviews | ESPEYB15

3.17 Diagnostic utility of molecular and imaging biomarkers in cytological indeterminate thyroid nodules

EJ de Koster , LF de Geus-Oei , OM Dekkers , I van Engen-van Grunsven , J Hamming , EPM Corssmit , H Morreau , A Schepers , J Smit , WJG Oyen , D Vriens

To read the full abstract: Endocr Rev 2018;39:154-191This extensive paper reviews current state of knowledge concerning possible diagnostic accuracy of all available biomarkers used for molecular diagnostics and in nuclear medicine for investigation of thyroid nodules of indeterminate cytology....