ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Curr Biol 2019;29:813–822 e4.In vertebrates, puberty is the critical transitional step which leads to major somatic changes and the acquisition of the reproduction function. At the molecular level, puberty equates to the reactivation of the gonadotropic axis after a period of childhood quiescence, and hence increases sex steroid production. This reactivati...

To read the full abstract: Endocr Pract 2018;24:565-572.Summary: According to this retrospective chart review of 34 transgender men, testosterone therapy in this population, across a wide range of doses and over many years, did not result in the profile of dyslipidemia and dysglycemia that is observed in women with polycystic ovary syndrome (PCOS). Instead, treatment of transgend...

Lancet Diabetes Endocrinol 2019 Published Online March 13, 2019. DOI: 10.1016/S2213-8587(19)30083-X• Practical challenges associated with diabetes care in humanitarian contexts in low- and middle- income countries abound.• In this position paper, the authors articulate the important needs around diabetes care in the context of the 6 building blocks ...

To read the full abstract: Pediatrics. 2018 Apr;141(4)See comment on 6.8....

To read the full abstract: J Adolesc Health. 2017 Jul;61(1):120-123Recent developments in assisted reproduction technologies (ART) have changed the scene for fertility wishes in a number of disorders, including GD. Fertility preservation is now routinely offered to postpubertal adolescent and adult GD patients at increasing numbers of medical centers. For biological boys, this is a non...

Ze’ev Hochberg was fascinated by growth, a dominant topic during his long-standing career. He published 153 articles on growth according to PubMed, the first 1980 [1] and the last in April this year [2]. Synergy between thyroid hormones and growth hormone was recognized decades ago [3] but Ze’ev Hochberg added an important piece of knowledge on the impact of hypothyroidism on the growth plate as well as the effects of thyroid hormones, growth hormone and the combinat...

Brief Summary: This study investigated the functional diversity of SOX9-positive pituitary stem cells (PSCs) using sophisticated murine transgenics combined with single-cell mRNA-seq (sc-mRNAsq). It identifies that the ability of Sox9+ve PSCs to maintain progeny varies depending on their location and surrounding context.The authors elegantly show that the SOX9 transcription factor marks a population of stem cells in the pituitary gland. The authors FAC-s...

Brief Summary: This meta-analysis of studies of classical CAH indicates that prenatal androgen exposure masculinizes and defeminizes play behavior in humans.Comment: Sex differences in juvenile-play behavior have been documented across a number of animal species, including non-human primates and in humans. It is proposed that juvenile play allows the developing individual to practice skills that are important for survival and adult social roles. In human...

Brief Summary: This case-series describes the clinical characteristics and genetics of 8 patients with hereditary hypophosphatemic rickets (HHR). It highlights the challenges faced in diagnosis and management.Hypophosphatemic rickets (HHR) is often underdiagnosed or misdiagnosed, leading to delays in proper treatment. Misdiagnosis can result in inappropriate therapies and worsening of the condition. The cases presented highlight the importance of compreh...

Pediatr Diabetes 2020;1–8. doi: 10.1111/pedi.13137– As part of the SWEET initiative, the authors analyzed the clinical characteristics of 26,726 individuals with type 1 diabetes (T1D) aged < 21 years living in Europe, Asia/Middle East/Africa, Australia/New Zealand, North America and South America– Among patient care indicators, the percent of HbA1c < 7.5% ranged between r...