ESPE Yearbook of Paediatric Endocrinology

Brief Summary: this longitudinal study found no statistical difference between boys and girls regarding the timing of increase in nocturnal luteinizing hormone concentrations.Puberty results from a gradual increase in GnRH secretion, that can be monitored by urinary gonadotropin measurements. Timing of normal puberty, initially described by Marshal and Tanner, is characterized by an important individual variability in humans1,2. The difference...

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Diabetes Care. 2020;43(2):484–486. doi: 10.2337/dc19-1487.This retrospective study in Quebec, Canada included 3,544 adolescents and young adults with diabetes and 1 388 397 without diabetes. It concludes that between the ages of 15 and 25 years, the risks of psychiatric disorders and suicide attempts were substantially higher in adolescents and young adults with diabetes than those without ...

Pediatrics 2021 Mar;147(3):e2020024182. 10.1542/peds.2020-024182 https://pubmed.ncbi.nlm.nih.gov/33526606/This sub-analysis of Teen-LABS study shows very similar improvements over 5 years after bariatric surgery between younger and older adolescents with severe obesity in %BMI change (−22.2% vs. −24.6%, respectively), resolution...

Diabetes. 2022 1;71(6):1233-1245. doi: 10.2337/db21-0992. PMID: 35294000.Brief Summary: This mouse model of diabetes tested the hypothesis that reducing the metabolic flux (rate of metabolism) in the beta cell can prevent beta-cell failure and preserve beta-cell mass. Reducing glucose metabolism may be a mechanism for preventing glucotoxicity-induced loss of functional beta-cell mass in diabetes. <...

J Bone Miner Res 36, 1387–1402. (2021)Abstract: https://pubmed-ncbi-nlm-nih-gov/33724538/In brief: Premature growth plate closure under anti-hedgehog treatment is caused by impaired retinoic acid metabolism in growth plate progenitor cells. In this mouse model, administration of retinoic acid receptor blockers rescued the phenotype and normalized growth plate maturation.<p class="a...

Lancet Diabetes Endocrinol. 2021; 9(12):876-892. PMID: 34798068https://pubmed.ncbi.nlm.nih.gov/34798068/Brief Summary: This review summarizes the current knowledge on the epidemiology, genetic background, pathophysiology, clinical presentation, diagnosis and treatment of primary aldosteronism.This review article on primary aldosteronism (PA) describes its clinical char...

gaetano.riemma@unicampania.it Cancers 2021, 13, 6331. PMID: 34944951.Brief Summary: This systematic review and meta-analysis examined the value of anti-Müllerian hormone (AMH) to predict premature ovarian failure (POI) in childhood cancer survivors (CCSs), compared to the general population.The potential toxic effect of alkylating agents and body irradiation on female...

Eur J Endocrinol 2021;185:K7–K11 doi: 10.1530/EJE-21-0312Brief Summary: Steroid profiling of 10 placentas of healthy full-term neonates (five male and five female) using liquid chromatography-tandem mass spectrometry revealed the presence of C11-oxy C19 steroids (androgens) in the fetal-placental unit at term – pointing to alternative androgen pathways in this unit.<p cla...

To read the full abstract: J Clin Endocrinol Metab. 2020;105:e774–e7781.This prospective non-randomized clinical trial investigated the effect of two-years levothyroxine treatment in children with subclinical hypothyroidism (TSH 5.0–9.9 mU/l with normal FT4 for two years preceding the study) starting at a mean age of 9 years. Capalbo et al. observed no change in IQ scores in 20 children after two-years of levothyroxine. Furthe...