ISSN 1662-4009 (online)

ey0018.2-14 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB18

2.14. Early diagnosed gestational diabetes mellitus is associated with adverse pregnancy outcomes: A prospective cohort study

B Liu , J Cai , Y Xu , Y Long , L Deng , S Lin , J Zhang , J Yang , L Zhong , Y Luo , Y Zhou , Y Zhang , Z Li , H Chen , Z Wang

J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa633. doi: 10.1210/clinem/dgaa633. PMID: 32898218.In this study, low risk pregnant women had an ‘early’ OGTT at 18-20 weeks of gestation and these results were correlated with the standard OGTT at 24-28 weeks. Pregnant women with Gestational diabetes mellitus (GDM) who had early OGTT still had a higher risk of delivering macrosomic in...

ey0018.13-11 | Endocrinology | ESPEYB18

13.11. Clinical characteristics of 46,XX males with congenital adrenal hyperplasia

S Savaş-Erdeve , Z Aycan , S Cetinkaya , AP Ozturk , F Bas , S Poyrazoglu , F Darendeliler , E Ozsu , Z Sıklar , M Demiral , E Unal , M Nuri Ozbek , F Gurbuz , B Yuksel , O Evliyaoglu , N Akyurek , M Berberoglu

J Clin Res Pediatr Endocrinol 2020 Dec 30.doi: 10.4274/jcrpe.galenos.2020.2020.0216– The characteristics of 44 patients with 46,XX congenital adrenal hyperplasia (CAH) who were raised as males were described– 15/44 (34%) were diagnosed before 2 years of age– The median final height was 149.2 (range 133–172) cmThis paper discusses an important ...

ey0019.3-11 | Autoimmune Thyroid Disease | ESPEYB19

3.11. Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto's thyroiditis

QY Zhang , XP Ye , Z Zhou , CF Zhu , R Li , Y Fang , RJ Zhang , L Li , W Liu , Z Wang , SY Song , SY Lu , SX Zhao , JN Lin , HD Song

Nat Commun. 2022 Feb 9;13(1):775. doi: 10.1038/s41467-022-28120-2. PMID: 35140214Brief Summary: This in vitro study identified interactions between distinct cell populations of the thyroid gland and immune cells in the context of Hashimoto thyroiditis. The authors provide important new insights into the pathological mechanism of Hashimoto thyroiditis by characterizing the stromal ...

ey0019.6-7 | Basic and Genetic Research of DSD | ESPEYB19

6.7. MAP3K1 variant causes hyperactivation of Wnt4/[beta]-catenin/FOXL2 signaling contributing to 46,XY disorders/differences of sex development

H Chen , Q Chen , Y Zhu , K Yuan , H Li , B Zhang , Z Jia , H Zhou , M Fan , Y Qiu , Q Zhuang , Z Lei , M Li , W Huang , L Liang , Q Yan , C Wang

Front Genet. 2022 Mar 3;13:736988. PMID: 35309143, doi: 10.3389/fgene.2022.736988.Brief Summary: This molecular study highlights a novel mechanism of action of Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) in the development of testicular dysgenesis.MAP3K1 is one of the most common genes that has been identified to cause 46, XY DSD and variants are attribu...

ey0019.5-10 | Translational highlights | ESPEYB19

5.10. INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice

Z Cheng , K O'Brien , J Howe , C Sullivan , D Schrier , A Lynch , S Jungles , Y Sabbagh , D Thompson

J Bone Miner Res. 2021 Aug;36(8):1594-1604.Abstract: https://pubmed-ncbi-nlm-nih-gov/33900645/In Brief: Enzyme replacement therapy with human ENPP1-Fc protein in Enpp1asj/asj mice, a murine model of ENPP1 deficiency, restored circulating levels of PPi, prevented clinical manifestations and decreased mortality.Commentary: ENPP1 deficiency causes gen...

ey0019.8-11 | New Concerns | ESPEYB19

8.11. Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis

Z Zajkowska , N Gullett , A Walsh , V Zonca , GA Pedersen , L Souza , C Kieling , HL Fisher , BA Kohrt , V Mondelli

Psychoneuroendocrinology. 2022; 136: 105625. PMID: 34920399https://pubmed.ncbi.nlm.nih.gov/34920399/Brief Summary: This is a systematic review and meta-analysis examined the relationship between cortisol and major depressive disorder in global youth (10–24 years old).Impaired regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the de...

ey0017.4-9 | New perspectives | ESPEYB17

4.9. Growth hormone deficiency and excess alter the gut microbiome in adult male mice

EA Jensen , JA Young , Z Jackson , J Busken , EO List , RK Carroll , JJ Kopchick , ER Murphy , DE Berryman

To read the full abstract: Endocrinology, April 2020, 161(4):1–18The aim of this study was to examine the role of growth hormone (GH) on gut microbiome and intestinal phenotype by using two animal models characterized by an opposite GH status: GH gene-disrupted (GH-/-) mice, characterized by GH deficiency; and bovine GH transgenic (bGH) mice with chronic GH excess. The abundance of common bacterial genera, such as Parasutterella, Ruminococc...

ey0017.15-18 | (1) | ESPEYB17

15.18. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

HJ Watson , Z Yilmaz , LM Thornton , C Hübel , JR Coleman , HA Gaspar , J Bryois , A Hinney , VM Leppä , M Mattheisen

To read the full abstract: This genome-wide association study (GWAS) of 16,992 cases of anorexia nervosa and 55 525 controls identified 8 significant loci. The findings show that the genetic architecture of anorexia nervosa mirrors its clinical features, showing significant genetic correlations with psychiatric disorders (obsessive-compulsive disorder, depression, anxiety, and schizophrenia), physical activity, and metabolic (including glycemic), lipid and anthropometric trait...

ey0016.5-1 | New Therapies and Novel Therapeutic Strategies | ESPEYB16

5.1. Cartilage-targeted IGF-1 treatment to promote longitudinal bone growth

JC Lui , M Colbert , CSF Cheung , M Ad , A Lee , Z Zhu , KM Barnes , DS Dimitrov , J Baron

Abstract: Mol. Ther. 2019;27:673–680.In brief: The authors developed a fusion protein containing a cartilage-targeting antibody fragment and Insulin-like growth factor 1 (Igf1) and demonstrate that it can stimulate growth plate cartilage at lower and less frequent doses than Igf1. This is a novel approach that paves the way for the development of tissue-specific target...

ey0015.11-15 | BAT: The story goes on | ESPEYB15

11.15 Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

J Chi , Z Wu , CHJ Choi , L Nguyen , S Tegegne , SE Ackerman , A Crane , F Marchildon , M Tessier-Lavigne , P Cohen

To read the full abstract: Cell Metab. 2018, 27, 226-236Upon sustained cold exposure, white adipose tissue (WAT) can undergo substantial remodeling, characterized by the appearance of thermogenic brown-like or beige adipocytes. This “browning” of white fat depot also happens in humans and is associated with anti-obesity and anti-diabetic effects. This is why WAT “browning&#...