ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Bone Miner Res. 2020;35(2):248–260.In brief: This randomized open-label trial in oligoamenorrheic athletes evaluated the effects of transdermal estrogen, oral estrogen or no replacement on bone metabolism, geometry, and microarchitecture. Transdermal estrogen treatment resulted in significantly greater increases in volumetric bone mineral d...

To read the full abstract: JAMA Pediatr. 2019 Oct 21;173(12):1137–45. doi: 10.1001/jamapediatrics.2019.3544.The authors describe a randomised controlled trial to decrease risks of sensitization to cow’s milk protein by avoiding supplementation with cow’s milk formula at birth. The trial included 330 newborns in Japan, where the practice of supplementing breastfeedin...

To read the full abstract: Pediatr Diabetes. 2018 Nov;19(7):1221–1228Despite good metabolic control some patients with type 1 diabetes (T1D) may develop comorbidities early while others despite high HbA1c levels remain free of complications for long durations. Risk factors for T1D complications are both of intrinsic (e.g. genetic) and extrinsic (e.g. environmental) origin. Amongst t...

To read the full abstract: Diabetes Care. 2019;42:1297–1304In normal populations, high BMI is associated with higher mortality and morbidity, in particular from cardiovascular disease (CVD). In contrast, in type 1 diabetes (T1D), low body weight has been associated with increased mortality risks. This study investigated the importance of weight and weight gain/loss in patients with ...

To read the full abstract: Diabetes Care. 2018;41:326-332The question whether or not T1DM patients with low HbA1c levels, which are thought to characterize good metabolic control, in fact experience hypoglycemia and most importantly severe hypoglycemia more frequently than T1DM patients with high HbA1c levels and hence worse metabolic control has been discussed controversially. However, it is commonl...

To read the full abstract: J Obes 2018;16:76-81In this study, a lower level of serum omentin-1 and a higher level of vaspin were detected in pubertal obese children with MetS compared with obese children without MetS. MetS is characterized by central obesity, and increased visceral adipose tissue mass is associated with higher prevalence of insulin resistance; these pose risks for T2DM and cardio...

Brief summary: This is the first multi-national phase 2 dose finding trial aimed at investigating efficacy and safety of the long acting GH (Somapacitan) with daily GH in short children born SGA. 62 GH treatment-naïve short children born SGA were enrolled in the study. Efficacy was valuated with estimated mean annualized height velocity (HV) after 26 weeks of follow-up. Somapacitan showed similar efficacy of daily rhGH. The study will be extended for further 4 years in or...

Brief Summary: This cross-sectional study aimed to define if childhood cancer was related to delayed achievement of psychosocial milestones in later life.Data of 252 male childhood cancer survivors (CCS) diagnosed with haematological or solid tumours between 1964 and 2000, with 6-42 years of survival, were collected and compared with 5 matched controls for each patient. CCS moved away from their parental home as frequently as population controls but were...

Brief Summary: This phase 2, double-blind, placebo-controlled trial, randomized 91 people (10-30 years-old) diagnosed with type 1 diabetes (T1D) within the previous 100 days to receive either oral baricitinib (n=60) or placebo (n=31) for 48 weeks. Baricitinib was safe and preserved the capacity of β-cells to secrete insulin.Baricitinib is a Janus kinase (JAK) inhibitor blocking cytokine signalling and is already an effective disease-modifying treatm...

Brief Summary: Circulating microRNAs (miRNA) were measured using multiplatform sequencing in longitudinal samples from 262 individuals with newly diagnosed type 1 diabetes (T1D) enrolled in the INNODIA Natural History Study. A set of miRNAs located within the T1D susceptibility chromosomal locus 14q32 distinguished 2 groups of T1D: those with higher miRNA expression showed better glycemic outcomes and immunomics profile.MicroRNAs (miRNAs) are a class of ...