ESPE Yearbook of Paediatric Endocrinology

Brief Summary: The authors performed exploratory analyses to identify distinct eGFR trajectories associated with risk of albuminuria in 377 adolescents with T2D. The findings underscore the importance of annual GFR assessments in young people with T2D.Comment: Diabetic kidney disease (DKD) is the primary microvascular complication in adolescents with T2D, and is a leading cause of morbidity and mortality. Albuminuria is the earliest clinical indicator of...

BMJ Open. 2020 Dec 24;10(12):e045335. doi: 10.1136/bmjopen-2020-045335. PMID: 33361084This BMJ review aimed to assess the accuracy of CGM devices to detect hypoglycaemia and hyperglycaemia in preterm infants. The key take home messages from the BMJ review were that the sensitivity for CGM devices to diagnose and detect hypoglycaemia in preterm infants was poor but the specificity was h...

Clin Endocrinol Metab. 2021;106(2):431–441. doi: 10.1210/clinem/dgaa842. PMID: 33205215This study aimed to describe the clinical characteristics of 6 patients with NPR2 gene mutations and the response to rhGH treatment in 2 of them.The natriuretic peptide receptor 2 gene (NPR2) is a paracrine factor involved in the regulation of cell proliferati...

J Pediatr Adolesc Gynecol. 2021 Apr;34(2):168–175. doi:10.1016/j.jpag.2020.11.012. PMID: 33248216The authors report the long-term outcomes of 71 patients with Complete Androgen Insensitivity Syndrome (CAIS) in the multicentre cross-sectional dsd-LIFE study. Patients were included at 14 different sites in 6 countries in Europe. This is one of the largest long-term studies on CAIS and is of interest to clinicians who manage girls and women wi...

J Clin Endocrinol Metab. 2021; 106(2): e957–e965.https://pubmed.ncbi.nlm.nih.gov/33135723/The authors investigated the reproductive and perinatal outcomes in women with congenital adrenal hyperplasia (CAH) compared with control women in the largest such population-based study to date. Women with CAH had lower birth rates, were more likely to develop gestational diabetes, and had other ...

Diabetes Care. 2020;43(10):2537–2543. doi: 10.2337/dc20-0736.This paper describes a randomized crossover trial in young people with T1D (16–24 years old) comparing two 8-week study periods: the factory-calibrated Dexcom G6 CGM system versus routine self-monitoring of blood glucose (SMBG). CGM improved time within glucose target and reduced HbA1c by 0.76%.The prim...

BMJ. 2020 Dec 10;371:m4337. doi: 10.1136/bmj.m4337.In brief: Owners of dogs which have with diabetes are more likely to develop T2DM themselves than owners of dogs without diabetes. The underlying mechanisms might include shared diabetogenic health behaviours and environmental exposures. No shared risk of diabetes was found between cat owners and their cats.Co...

Front Endocrinol 2021; 12:624507. doi: 10.3389/fendo.2021.624507– This systematic review identified 41 Chinese studies totalling 7,853,756 newborns who underwent neonatal CAH screening– The overall incidence of CAH in China was 1/23,024 (95% CI, 1/25,757 to 1/20,815)– Among the CAH patients, the Male:Female ratio was 1.92:1, and 76% presented with salt wasting<p class=...

Human Reproduction, 2021; 36(7): 1948–1958https://bit.ly/3vtcByFThis cross-sectional study shows that men who had been exposed in utero to endocrine disruptors (EDC) are twice more likely to have a low sperm count, below the reference values per ejaculation set by the World Health Organisation.Male reproductive function is known to be highly sensitive to a number of chemical compou...

Hormone Research in Paediatrics 2020;93:548–557https://bit.ly/2ToJvmvThe authors studied 2,657 German children aged 5-18 years to look for social patterning in the age at puberty timing and circulating gonadotrophin levels. Lower socio-economic status (SES) was associated with earlier thelarche, longer duration of puberty, and overweight in girls, but not age at menarche. In boys, lower SES showed a tren...