ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 8 of about 293 results

ey0015.8-5 | New Mechanisms | ESPEYB15

8.5 Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla

A Furlan , V Dyachuk , ME Kastriti , L Calvo-Enrique , H Abdo , S Hadjab , T Chontorotzea , N Akkuratova , D Usoskin , D Kamenev , J Petersen , K Sunadome , F Memic , U Marklund , K Fried , P Topilko , F Lallemend , PV Kharchenko , P Ernfors , I Adameyko

To read the full abstract: Science. 2017; 357(6346)Current textbooks teach that adrenergic chromaffin cells of the adrenal medulla originate from a sympathoadrenal cell lineage of the neural crest nearby the dorsal aorta. Here, Furlan et al. demonstrate a novel origin of these neuroendocrine cells of the medulla arising predominantly from Schwamm cell precursors (SCP) of peripheral nerves. Prev...
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ey0020.8-13 | New Mechanisms | ESPEYB20

8.13. Low-dose IL-2 reduces IL-21(+) T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

JY Zhang , F Hamey , D Trzupek , M Mickunas , M Lee , L Godfrey , JHM Yang , ML Pekalski , J Kennet , F Waldron-Lynch , ML Evans , TIM Tree , LS Wicker , JA Todd , RC Ferreira

Brief summary: This study used high-resolution single-cell multiomics and flow cytometry on blood samples from patients with type 1 diabetes (T1D) to examine the effects of low-dose recombinant IL-2 (iLD-IL-2). Administration of iLD-IL-2 expanded thymic-derived FOXP3+HELIOS+ Tregs and CD56bright NK cells, reduced frequency of IL-21-producing CD4+T cells, and induced long-lived anti-inflammatory transcriptional changes in all T and NK...
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ey0018.2-20 | Maternal Obesity and Long-term Infant Consequences | ESPEYB18

2.20. Maternal obesity influences placental nutrient transport, inflammatory status, and morphology in human term placenta

P Nogues , E Dos Santos , A Couturier-Tarrade , P Berveiller , L Arnould , E Lamy , S Grassin-Delyle , F Vialard , MN Dieudonne

J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1880–e1896. doi: 10.1210/clinem/dgaa660. PMID: 32936881.By studying placentas from normal weight mothers and obese (non-diabetic) mothers, the authors found that maternal obesity was associated with lower expression of nutrient transporters (such as for glucose and amino acids), surprisingly fewer immune cells, and compromised endocrine func...
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ey0018.9-7 | Surveillance strategies of endocrine complications | ESPEYB18

9.7. Hormonal replacement therapy in adolescents and young women with chemo- or radio-induced premature ovarian insufficiency: Practical recommendations.

A Cattoni , F Parissone , I Porcari , S Molinari , N Masera , M Franchi , S Cesaro , R Gaudino , P Passoni , A. alessandro.cattoni@unimib.it Balduzzi

Blood Rev. 2021; 45: 100730. https://pubmed.ncbi.nlm.nih.gov/32654893/This practical treatment protocol was developed by an experienced multidisciplinary team following a critical and updated systematic review of the literature.Hypogonadism is a common finding after antineoplastic treatment. It can either result from a primary gonadal disorder (due to pelvic irradiati...
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ey0019.3-4 | Thyroid development | ESPEYB19

3.4. Transcriptomic signature of human embryonic thyroid reveals transition from differentiation to functional maturation

G Dom , P Dmitriev , MA Lambot , Vliet G Van , D Glinoer , F Libert , A Lefort , JE Dumont , C Maenhaut

Front Cell Dev Biol. 2021 Jun 11;9:669354. doi: 10.3389/fcell.2021.669354. eCollection 2021. PMID: 34249923Brief Summary: This in vitro study analyzed the transcriptome of the developing thyroid gland in human embryonic thyroids compared to non-thyroidal human embryonic tissues and adult thyroid and adult non-thyroidal tissues. They identified four differently regulated sets of gen...
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ey0019.5-14 | Translational highlights | ESPEYB19

5.14. Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome

L Sedes , E Wondimu , B Crockett , J Hansen , A Cantalupo , K Asano , R Iyengar , D.B Rifkin , S Smaldone , F Ramirez

Hum Mol Genet ddac107 (2022)Abstract: https://pubmed.ncbi.nlm.nih.gov/35567544/In Brief: Disproportionate tall stature represents a hallmark feature of Marfan syndrome, although specific mechanisms underlying linear bone overgrowth are unclear. This study used an ex vivo model system to identify dysregulation of TGFβ-binding proteins in the outer perichondrium as causative for the bon...
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ey0019.9-10 | Fertility issues and reproductive outcomes in childhood cancer survivors | ESPEYB19

9.10. In male Hodgkin lymphoma patients, impaired fertility may be improved by non-gonadotoxic therapy

Laddaga F.E. , Masciopinto P. , Nardelli C. , Vacca M.P. , Masciandaro P. , Arcuti E. , Cicinelli E. , Specchia G. , Musto P. , Gaudio F.

fragaudio@alice.it British Journal of Haematology, 2022, 196, 110–115. PMID: 34462914.Brief Summary: This prospective single-centre study evaluated fertility in men diagnosed with Hodgkin lymphoma (HL) by sperm analysis, in order to identify clinical and biological characteristics correlated with fertility status. Only 28% of men showed normal sperm analysis.Previous studies in ...
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ey0019.10-8 | New paradigms | ESPEYB19

10.8. Insulin is expressed by enteroendocrine cells during human fetal development

A Egozi , D Llivichuzhca-Loja , BT McCourt , K Bahar Halpern , L Farack , X An , F Wang , K Chen , L Konnikova , S Itzkovitz

Nat Med. 2021 Dec;27(12):2104-2107. https://pubmed.ncbi.nlm.nih.gov/34887578/Brief Summary: This study used single-cell transcriptomic analyses to generate a cell atlas of the human fetal and neonatal small intestine. Notably, the authors identified a subset of fetal enteroendocrine K/L cells (named FIKL) that express high levels of insulin and other beta cell genes.T...
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ey0019.13-6 | Improving access to healthcare in pediatric endocrinology and diabetes | ESPEYB19

13.6. Access to fludrocortisone and to hydrocortisone in children with congenital adrenal hyperplasia in the WHO Eastern Mediterranean region: it takes a village…

A Rowlands , A Deeb , A Ladjouze , RT Hamza , SA Musa , J Raza , F Jennane , A Abu-Libdeh , JP Chanoine , the GPED CAH Working Group

jchanoine@cw.bc.ca BMJ Global Health 2021;6:e007195. doi: 10.1136/bmjgh-2021-007195Brief Summary: This review found that access to oral fludrocortisone and hydrocortisone remains suboptimal in the WHO Eastern Mediterranean Region. Improvement requires a collaboration between health professionals, families of patients, health authorities, pharmaceutica...
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ey0019.14-11 | Risk and Outcome | ESPEYB19

14.11. SGA-born adults with postnatal catch-up have a persistently unfavourable metabolic health profile and increased adiposity at age 32 years

Goedegebuure Wesley J. , Van der Steen Manouk , Smeets Carolina CJ , Kerkhof Gerthe F , Hokken-Koelega Anita CS

European Journal of Endocrinology (2022)187:15–26 doi: 10.1530/EJE-21-1130Brief Summary: This study, PROGRAM32, investigated 287 adults mean age 32 years who had participated 10 years earlier in the PROGRAM study on the metabolic and cardiovascular consequences of low birth weight (LBW). The aim was to investigate the adverse metabolic profile of being small for gestational age with spontane...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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