ESPE Yearbook of Paediatric Endocrinology

Brief summary: This multicenter, randomized, controlled, phase 3 study compared the effects of long-acting GH (Somapacitan; 0.16 mg/kg/wk) with daily GH (Norditropin; 0.034 mg/kg/d), in GHD children. The trial was conducted over 52 weeks, followed by an ongoing 3-year single-group extension period. Similar efficacy and safety for somapacitan compared to daily GH was demonstrated over 52 weeks of treatment.Long-acting growth hormone (LAGH) formulations ha...

Nature Metabolism. 2020;2(2):192–209. doi: 10.1038/s42255-020-0171-3.This experimental mouse study examined whether or not dedifferentiated β cells could be reversed or targeted by pharmacological intervention for diabetes remission. They identified evidence for β-cell dedifferentiation and dysfunction which could be reversed by single and combined pharmacological approach...

Brief Summary:This study uncovers a novel mechanism for the anti-inflammatory effects of glucocorticoids (GCs) that involves reprogramming of mitochondrial metabolism in macrophages through enhanced production of the anti-inflammatory metabolite itaconate and consequent inhibition of the inflammatory response. GCs have very potent anti-inflammatory properties, but the mechanisms are incompletely understood. GCs also have severe side effects when used in high doses for long-ter...