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14.16. The mutational landscape of human somatic and germline cells

Moore Luiza , Cagan Alex , Coorens Tim H H , Neville Matthew D C , Sanghvi Rashesh , Sanders Mathijs A , Oliver Thomas R W , Leongamornlert Daniel , Ellis Peter , Noorani Ayesha , Mitchell Thomas J , Butler Timothy M , Hooks Yvette , Warren Anne Y , Jorgensen Mette , Dawson Kevin J , Menzies Andrew , O'Neill Laura , Latimer Calli , Teng Mabel , van Boxtel Ruben , Iacobuzio-Donahue Christine A , Martincorena Inigo , Heer Rakesh , Campbell Peter J , Fitzgerald Rebecca C , Stratton Michael R , Rahbari Raheleh

Nature. 2021 Sep;597(7876):381386. doi: 10.1038/s41586-021-03822-7.Brief Summary: This study investigated the mutational background of somatic cells and rates of mutation in 29 distinct anatomical structures and compared these with the male germline from the same donor. The rate of mutation was lowest in spermatogonia.Characterization of mutations that occur in...

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ey0020.13-2 | Section | ESPEYB20

13.2. Somatic mutation rates scale with lifespan across mammals

A Cagan , A Baez-Ortega , N Brzozowska , F Abascal , THH Coorens , MA Sanders , ARJ Lawson , LMR Harvey , S Bhosle , D Jones , RE Alcantara , TM Butler , Y Hooks , K Roberts , E Anderson , S Lunn , E Flach , S Spiro , I Januszczak , E Wrigglesworth , H Jenkins , T Dallas , N Masters , MW Perkins , R Deaville , M Druce , R Bogeska , MD Milsom , B Neumann , F Gorman , F Constantino-Casas , L Peachey , D Bochynska , ESJ Smith , M Gerstung , PJ Campbell , EP Murchison , MR Stratton , I Martincorena

In Brief: To document variations in rates of somatic mutations, the authors performed whole-genome sequencing of DNA from cells of intestinal crypts across 16 diverse mammalian species, spanning huge 40 000-fold variations in body mass and 30-fold variations in lifespan. The somatic mutation rates per year varied greatly across species and showed a much stronger inverse relationship with species lifespan than with species body mass.Comment: Petos p...

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ESPE Yearbook of Paediatric Endocrinology

14.16. The mutational landscape of human somatic and germline cells

13.2. Somatic mutation rates scale with lifespan across mammals

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