ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0020.12-11 | Basic Research | ESPEYB20

12.11. Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

I Gonzalez-Garcia , E Garcia-Clave , A Cebrian-Serrano , O Le Thuc , RE Contreras , Y Xu , T Gruber , SC Schriever , B Legutko , J Lintelmann , J Adamski , W Wurst , TD Muller , SC Woods , PT Pfluger , MH Tschop , A Fisette , C Garcia-Caceres

Brief summary: This basic science study in mice shows how melanocortin neurons integrate reproductive signaling with energy homeostasis. In melanocortin neurons, estradiol (E2) enhances the anorectic action of leptin. Cited1 is enriched in these neurons and its loss exacerbates diet-induced obesity in female mice. Using several specific mouse models it is demonstrated how hypothalamic Cited1, via ERĪ± and Stat3 interactions, link the effects of E2 and leptin on food intake...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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