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ey0021.4-4 | Important for Clinical Practice | ESPEYB21

4.4. Recombinant human insulin-like growth factor-1 treatment of severe growth failure in three siblings with STAT5B deficiency

G Muthuvel , SS Al Remeithi , C Foley , A Dauber , V Hwa , P Backeljauw

Brief Summary: This case series describes the effect of recombinant human IGF-1 (rhIGF-1) administration on growth of three siblings with STAT5B homozygous recessive mutations.The peripheral effects of GH are primarily mediated by IGF-I through the activation of the GH receptor (GHR)-signal transducer and activator of transcription (STAT)-5B signaling. Patients carrying STAT5B mutations have severe postnatal growth failure and IGF-I deficiency a...

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ey0018.12-9 | Metabolic Syndrome | ESPEYB18

12.9. Sugar-Induced obesity and insulin resistance are uncoupled from shortened survival in drosophila

E Van Dam , LAG van Leeuwen , E Dos Santos , J James , L Best , C Lennicke , AJ Vincent , G Marinos , A Foley , M Buricova , JB Mokochinski , HB Kramer , W Lieb , M Laudes , A Franke , C Kaleta , HM Cocheme

Cell Metab. 2020; 31(4):710725.e7. doi: 10.1016/j.cmet.2020.02.016. PMID: 32197072.In brief: High-sugar diets cause thirst, obesity and metabolic dysregulation, leading to insulin resistance, the MetS, T2DM and shortened lifespan. This study shows that high sugar diets induce dehydration in adult Drosophila. Water supplementation fully rescued the shortened lifespan, but ...

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ESPE Yearbook of Paediatric Endocrinology

4.4. Recombinant human insulin-like growth factor-1 treatment of severe growth failure in three siblings with STAT5B deficiency

12.9. Sugar-Induced obesity and insulin resistance are uncoupled from shortened survival in drosophila

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