ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Front. Endocrinol. 2020; 11:106. doi: 10.3389/fendo.2020.00106• The authors assessed the relationship between markers of a stressful environment and final height in adult men and women in 71 countries (including 31 countries that are members of the Organisation for Economic Co-operation and Development [OECD]).• They found that the more stressful the e...

Brief summary: The authors assessed the relationship between markers of a stressful environment and final height in adult men and women in 71 countries (including 31 countries that are members of the Organisation for Economic Co-operation and Development [OECD]). They found that the more stressful the environment, the shorter the adult height. By order of decreasing importance, the relationship between markers of a stressful environment and height were income inequality > ...

Brief summary: This prospective study, including 380 American girls followed from birth to age 15.5 years between 1991 and 2006, showed the predictive nature of age at onset of puberty for the subsequent progression and duration of pubertal maturation.Ze’ev Hochberg’s scientific and clinical curiosity is an inspiration for us all. Ze’ev approached the topic of puberty using evolutionary and developmental biology principles, according to wh...

Thyroid. 2021;31:202–207. doi: 10.1089/thy.2020.0253.This study describes a new genetic thyroid disease that might be unnoticeable in individuals with normal thyroid synthetic capacity, but may cause harm in all patients who are dependent on levothyroxine substitution such as congenital hypothyroidism, acquired hypothyroidism, or post-thyroidectomy.Three iodothyro...

Brief summary: In this paper introduced a new energy trade-off score (ETOS) and index to characterize four extreme human body types regarding height and weight in young adulthood (e.g. tall-slender, short-stout, short-slender, tall-stout) for growth patterns and underlying genetic background. Growth data of 1889 subjects (996 girls) of the GrowUp 1974 Gothenburg study were investigated for the four body types showing that the two trade-off body types tall-slender<...

J Clin Endocrinol Metab. 2021; 16;106(7):e2700–e2710.PMID: 33606028 doi: 10.1210/clinem/dgab093This paper illustrates the power of machine learning to successfully predict adult height using growth measurements before age 6 years, without the need for bone age.Computers beat us in games of predictions, such as chess. They beat us also in the exercise of predictin...

Brief summary: Growth data from three independent longitudinal cohort studies (Gothenburg GrowUp 1974 (n 1596); Gothenburg GrowUp 1990 (n 1890); Edinburgh Growth Study (n 145)) were used to train machine learning (ML) to predict adult height (AH) based on growth measurements until the age of 6 years. Five ML algorithms were tested. A random forest model predicted best, with sex and height at age 3.4–6.0 years being the most influencing factors. The model was cross-validat...

Brief Summary: This multicentre retrospective cross-sectional study provides critical insights into the epidemiology, clinical presentation, and neurodevelopmental outcomes of central congenital hypothyroidism (CCH).CCH is a rare disorder that occurs due to insufficient hypothalamic-pituitary stimulation of the thyroid, characterized by low total T4 (TT4) with either low, normal or slightly elevated TSH. Most newborn screening (NBS) programs for CH are p...

To read the full abstract: Pediatr Diabetes. 2018;19:1471–1480It has been debated whether or not new technologies, in particular the combination of insulin pumps and continuous glucose testing, will improve patient satisfaction and quality of life rather than only metabolic control and risk of microvascular complications. Indeed, the use of continuous subcutaneous insulin infusion (...

To read the full abstract: J Clin Endocrinol Metab. 2019; 104(8): 3172–3180. PMID: 30865229.Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency was among the first genetic disorders included in newborn screening (NBS) programs worldwide, based on 17-hydroxyprogesterone (17OHP) concentrations determined in dried blood spots (1). However, the success of NBS for...