ESPE Yearbook of Paediatric Endocrinology

In Brief: The authors investigated intraperson variability in fasting glucose (FG) levels using continuous glucose monitoring (CGM) devices in 8315 nondiabetic adults aged 40–70 years. Day-to-day intraperson standard deviation of FG was 7.52 mg/dl (0.42 mol/l). This high variability has a large estimated impact on the classification of glycemic status (normal FG, prediabetes or diabetes). Of 5328 adults classified as having normal FG based on their Day 1 measurement, 40% ...

To read the full abstract: Nature 2018;555:210Up to now, it was thought that genetics would play a major role in shaping the gut flora. However, this study, in a cohort of 1,046 healthy Israeli individuals with a well-defined clinical phenotype, suggests that only 2-8% of human microbiome variability is explained by genetics, as compared to 92-98% explained by environmental influences. This...