ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Endocrinology 2019;160:557–567.There is now no doubt that arcuate nucleus (ARC) kisspeptin neurons are the GnRH pulse generator. The authors analyzed the activity of ARC kisspeptin neurons by using a very powerful method based on the recording of calcium concentration within cells.ARC kisspeptin neurons activity was analyzed in male ...

To read the full abstract: Endocrinology 2019;160:1480–1491.There is now no doubt that arcuate nucleus (ARC) kisspeptin neurons are the GnRH pulse generator. (With paper 1.8) this second paper describes the activity of the GnRH pulse generator across the estrous cycle. In this work, the variable level of E2 represented an additional complexity. The second interest was to understand ...

To read the full abstract: Elife. 2018 Jun 15;7. pii: e35960.Using transgenic mice, this team discover a new role for Pituitary adenylate cyclase activating polypeptide (PACAP) in female puberty and reproduction. This neuropeptide relays nutritional state information in the hypothalamus to regulate gonadotropin-releasing hormone release.Metabolic cues play...

To read the full abstract: Nat Commun 2018;9.400Pheromones play a crucial role to identify potential mates and sexual motivation in mice. These molecules are detected by a specialized circuit which initiates in the nasal septum and then relies on GnRH neurons in the hypothalamus in a sex-dependent manner. Female pheromones induce LH/testosterone release in male mice whereas male pheromones i...