ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: PLoS Genet. 2020;16:e1008770.Præstholm et al. quantified by a genomics approach histone H3 acetylation – an epigenetic mark for DNase accessible chromatin – at thyroid hormone target gene enhancers to challenge the current model of genome binding action of T3 (type 1 action of thyroid hormone receptors (TR)) [1]. For this, they investigated genome-wide the liver of WT mice at hypothyroid and hyp...

Brief Summary: This study examined the regulation of thyroid hormone (TH) levels by thyrotropin-releasing hormone (TRH) neurons located in the paraventricular nucleus (PVN) of the hypothalamus in fed and fasted mice. It focused on the role of agouti-related peptide (AgRP)/neuropeptide Y (NPY) neurons in the arcuate nucleus.Using chemogenetic activation in mice, the authors demonstrated that TRH neurons play a direct role in regulating the hypothalamic-pi...

To read the full abstract: Development 2017;144:3879-3893Regenerative medicine techniques are being widely investigated for organs without regenerative capacity, such as lung. Whether pluripotent stem cell derived thyroid organoids will be used in the future as a regenerative medicine approach to treat hypothyroidism is unclear. In the context of an easily available, very cheap and non-in...