ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Clin Endocrinol Metab. 2019;104:5540–5546.This single center, retrospective study analyzed the prevalence and natural history of amiodarone associated thyroid disease in 190 children and young adults with detailed thyroid function tests. Amiodarone induced hypothyroidism (AIH) and thyrotoxicosis (AIT) are well known entities due to direct thyroid toxicity. Further, subclinical hypothyroidism (SCH) is caused by a...

Brief summary: Treatment of Graves’ disease comprises anti-thyroid drugs, radioactive iodine ablation or total thyroidectomy (1,2). While definitive treatment of Graves’ disease is widely used in adults, anti-thyroid drug treatment is often used in the pediatric age group over years (1,2). The presented prospective monocenter study provides detailed information on quality of life of adolescents undergoing total thyroidectomy.Two recent studies ...

moab@chop.edu Pediatr Blood Cancer. 2022; 69: e29674. PMID: 35338690.Brief Summary: Childhood cancer survivors (CCS), particularly those exposed to local irradiation, are at increased risk for thyroid disease and thyroid surgery. This retrospective, monocentric study compared rates of surgical complications among 42 CCS undergoing thyroid surgery compared to 596 non-CCS controls (sporadic/familial thyroid cance...

Brief Summary: This retrospective study assessed the outcome of thyroid ultrasound (US) surveillance in childhood cancer survivors (CCS) exposed to radiotherapy (RT). 306 CCS were monitored with thyroid US. Patients received TBI (45%) and/or RT to craniospinal (44%), chest (11%), and neck regions (6%). Thyroid US surveillance was started at a median interval of 9.1 years after RT; 150 patients (49%) had thyroid nodule(s); 44 patients underwent surgery, and 28 had a final diagn...

J Clin Oncol. 2022 Apr 1;40(10):1081-1090. doi: 10.1200/JCO.21.01861. Epub 2022 Jan 11. PMID: 35015563Brief Summary: This retrospective monocenter study of clinical, pathological and molecular analysis of n=113 children with differentiated thyroid cancer (DTC) showed that genetic analysis of DTC provided more accurate information on prognosis and outcome than classical histological categorizatio...