ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 6 results

ey0021.7-4 | Clinical Guidance and Studies | ESPEYB21

7.4. Unstimulated luteinizing hormone for assessment of suppression during treatment of central precocious puberty with 6-month subcutaneous leuprolide acetate: correlations with clinical response

KO Klein , BS Miller , N Mauras

Brief Summary: This prospective study of 62 children with Central Precocious Puberty (CPP) concluded that measuring unstimulated luteinizing hormone (LH) may be adequate to assess effective pubertal suppression.Pubertal stages, growth velocity and bone age maturation are considered as key clinical markers to evaluate adequate pubertal suppression in patients treated for CPP. Basal LH concentrations levels also seem to be effective1. This study...
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ey0016.10-1 | (1) | ESPEYB16

10.1. Transition to adult diabetes care in Germany - high risk for acute complications and declining metabolic control during the transition phase

TM Kapellen , S Muther , A Schwandt , J Grulich-Henn , B Schenk , KO Schwab , W Marg , RW Holl

Pediatr Diabetes. 2018 Apr 25. doi: 10.1111/pedi.12687. [Epub ahead of print]Transition of patients with chronic diseases from pediatric to adult care has become recognized as an important part of health care provision and its multifaceted challenges are increasingly being studied. This transition period is associated with deterioration of metabolic control and general health in young adults wi...
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ey0018.7-3 | Clinical Guidance | ESPEYB18

7.3. Phase 3 trial of a small-volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty

KO Klein , A Freire , MG Gryngarten , GB Kletter , M Benson , BS Miller , TS Dajani , EA Eugster , N Mauras

J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3660–71. 10.1210/clinem/dgaa479. https://academic.oup.com/jcem/article/105/10/e3660/5879679In brief: This phase 3 multi-centre, open-label, single-arm study explores the efficacy, pharmacokinetics and safety of 6-monthly 45-mg subcutaneous leuprolide acetate in 59 pati...
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ey0015.14-9 | The ancient wisdom of refraining from consanguinity | ESPEYB15

14.9 Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers

M Sikora , A Seguin-Orlando , VC Sousa , A Albrechtsen , T Korneliussen , A Ko , S Rasmussen , I Dupanloup , PR Nigst , MD Bosch

To read the full abstract: Science 2017:eaao1807Consanguinity is common in some modern cultures. This study examined the question whether ancient humans, who often had limited choices of mates, bred among close relatives. Here, Sikora et al. report genome sequences from 4 early humans buried close together in western Russia about 34,000 years ago. The individuals ...
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ey0020.2-8 | Long-Acting Growth Hormone (LAGH) | ESPEYB20

2.8. Efficacy and safety of weekly somatrogon vs daily somatropin in children with growth hormone deficiency: A phase 3 study

CL Deal , J Steelman , E Vlachopapadopoulou , R Stawerska , LA Silverman , M Phillip , HS Kim , C Ko , O Malievskiy , JF Cara , CL Roland , CT Taylor , SR Valluri , MP Wajnrajch , A Pastrak , BS Miller

Brief summary: This 12-months randomized, controlled, phase 3 study compared the efficacy and safety of once-weekly Somatrogon 0.66 mg/kg/week with once-daily somatropin in prepubertal children with GHD. The efficacy of once-weekly Somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles.Somatrogon (MOD-4023) is a long-acting rhGH recently approved by the European Medicines Agency for the treatment of children wi...
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ey0021.2-9 | Important Associations with Growth | ESPEYB21

2.9. The associations between maternal and fetal exposure to endocrine- disrupting chemicals (EDC) and asymmetric fetal growth restriction: a prospective cohort study

S Hong , BS Kang , O Kim , S Won , HS Kim , JH Wie , JE Shin , SK Choi , YS Jo , YH Kim , M Yang , H Kang , D-W Lee , IY Park , JS Park , HS Ko

Brief Summary: This prospective cohort study of 146 mother-neonate pairs determined fetal-maternal exposure to EDCs from October 2021 – October 2022 and examined their associations with fetal growth parameters. Fetal exposure to bisphenol-A (BPA) showed a linear association with asymmetric fetal growth patterns.Their definition of fetal growth restriction (FGR) when assessed by transabdominal ultrasonography at 38.3 weeks gestational age was a fetal...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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