ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Lancet Glob Health 2017; 5(12):e1249-e1257This paper adds to the understanding of the factors underlying stunting in low-and middle-income countries (LMIC), a phenomenon that is adaptive to undernutrition, and associates with overall poorer health status and unfavorable social determinants of health. Previously thought to be secondary to predominantly individual...

To read the full abstract: Science 2018;361:76–81.The tuberal nucleus (TN) is a hypothalamic region which is well described in humans but remains poorly defined in rodents. In this paper, the authors demonstrated by specific and sophisticated techniques the role of somatostatin expressing TN (TNSST) neurons in the control of food intake in mice. Interestingly, their resul...

Brief Summary: This study examined resistance to thyroid hormone (TH)-induced tachycardia in patients with Resistance to THα (RTHα). This rare condition is caused by mutations in the TH receptor alpha (TRα1), and leads to hypothyroidism in TRα1-expressing tissues, including the heart. While high doses of thyroxine (T4) are typically used to treat this condition, patients with RTHα do not exhibit the expected increase in heart rate despite overcoming ti...