ESPE Yearbook of Paediatric Endocrinology

Eur Psychiatry. 2019 Jan;55:61–66.doi: 10.1016/j.eurpsy.2018.09.003. PubMed ID: 30390473Is the prevalence of gender dysphoria today truly increasing, or do the increasing numbers result because today’s world is more open so that these individuals and families no longer hide in the closet? Or are methodological factors playing a role? Fact is that in Eu...

To read the full abstract: J Pediatr. 2018 Jul;198:260–264This study aimed to analyze growth hormone (GH) doses and first-year growth response in prepubertal patients with the combination of type 1 diabetes (T1D) and growth hormone deficiency (GHD).A total of 69 patients with T1D and GHD treated with GH have been enrolled in KIGS (Pfizer International Growth D...

To read the full abstract: J Pediatr 2018; 198: 260-264The incidence of T1DM in children <15 years is increasing at an overall annual relative rate of 3.9% (95% CI 3.6-4.2) [11]. The prevalence of GHD is estimated at approximately 1:4000 to 1:10000 [12-14]. Management of the very rare patients who have both T1DM and GHD raises questions of efficacy and safety of ...

To read the full abstract: Front Endocrinol (Lausanne). 2018 Feb 28;9:54Secular trends in birth parameters1-3, growth4,5, and timing of puberty6-8 are observed in normal populations. Changes in nutrition, better access to health care, and other environmental factors have been implicated as causative factors for those changes. Here, the authors assessed secular ...

To read the full abstract: J Clin Endocrinol Metab 2017; 102:1702-1711Short stature is a common feature of children with Prader-Willi syndrome (PWS) as well as hypotonia, hyperphagia, obesity, hypogonadism, behavioral disturbances and hypothalamic dysfunction. Alterations in the GH/IGF1 axis are common in patients with PWS, GH deficiency occurring in approximately 74% and IGF-1...

J Clin Endocrinol Metab. 2020;105:3203–3214. doi: 10.1210/clinem/dgaa443. PMID: 32652002The authors performed a large genome-wide association study (GWAS) to assess the role of common genetic variants in the response to GH therapy. A total of 614 children treated with GH were included: 276 with idiopathic GHD, 297 with ISS, and 41 born SGA. The findings implicate some novel mechanisms...