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ey0020.2-5 | Important for Clinical Practice | ESPEYB20

2.5. Tracking and cumulative lifetime exposure to IGF-I in 6459 healthy individuals and in SGA children treated with GH

ASL Kjaer , RB Jensen , JH Petersen , A Linneberg , LL Karhus , LS Henriksen , TH Johannsen , KM Main , AR Hoffman , A Juul

Brief summary: The objective of this study was to examine whether IGF-I and IGF-binding protein-3 (IGFBP-3) levels track through childhood into adulthood and to estimate the cumulative lifetime exposure to IGF-I in healthy individuals and in individuals with a defined period of increased IGF-I levels because of GH therapy.Measurement of serum IGF-I is a cornerstone in rhGH treatment monitoring. Keeping serum IGF-I concentrations within the normal referen...

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ey0017.7-2 | Clinical Guidance | ESPEYB17

7.2. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

H Frederiksen , TH Johannsen , SE Andersen , J Albrethsen , SK Landersoe , JH Petersen , AN Andersen , ET Vestergaard , ME Schorring , A Linneberg , KM Main , AM Andersson , A Juul

To read the full abstract: Journal of clinical endocrinology and metabolism vol. 105,3 (2020):754768. doi: https://academic.oup.com/jcem/article/105/3/754/5624050The authors used state-of-the-art liquid chromatography tandem mass spectrometry to establish sex-specific reference ranges for estrone (E1) and estradiol (E2) throughout life and evaluate sex-differences.</...

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ey0016.11-4 | New Insights into Body Weight Regulation | ESPEYB16

11.4. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

OS Dallner , JM Marinis , YH Lu , K Birsoy , E Werner , G Fayzikhodjaeva , BD Dill , H Molina , A Moscati , Z Kutalik , P Marques-Vidal , TO Kilpelainen , N Grarup , A Linneberg , Y Zhang , R Vaughan , RJF Loos , MA Lazar , JM Friedman

To read the full abstract: Nature Medicine 2019; 25(3):507-516.This paper shows that quantitative leptin expression is controlled by redundant cis elements and trans factors that interact with the proximal promoter together with a long noncoding RNA.Friedmans research group discovered the adipocyte hormone leptin more than 20 years ago. They identified loss o...

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ESPE Yearbook of Paediatric Endocrinology

2.5. Tracking and cumulative lifetime exposure to IGF-I in 6459 healthy individuals and in SGA children treated with GH

7.2. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

11.4. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

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