ISSN 1662-4009 (online)

ey0019.7-13 | Basic Science | ESPEYB19

7.13. Multi- and transgenerational outcomes of an exposure to a mixture of endocrine-disrupting chemicals (EDCs) on puberty and maternal behavior in the female rat

D Lopez-Rodriguez , CF Aylwin , V Delli , E Sevrin , M Campanile , M Martin , D Franssen , A Gerard , S Blacher , E Tirelli , A Noel , A Lomniczi , AS Parent

Environ Health Perspect.2021 Aug;129(8):87003. doi: 10.1289/EHP8795. Epub 2021 Aug 12. PMID: 34383603. https://ehp.niehs.nih.gov/doi/10.1289/EHP8795?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedBrief Summary: Using a rode...

ey0017.8-12 | New Hope | ESPEYB17

8.12. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

J Zein , B Gaston , P Bazeley , MD DeBoer , RP Jr Igo , ER Bleecker , D Meyers , S Comhair , NV Marozkina , C Cotton , M Patel , M Alyamani , W Xu , WW Busse , WJ Calhoun , V Ortega , GA Hawkins , M Castro , KF Chung , JV Fahy , AM Fitzpatrick , E Israel , NN Jarjour , B Levy , DT Mauger , WC Moore , P Noel , SP Peters , WG Teague , SE Wenzel , SC Erzurum , N Sharifi

To read the full abstract: Proc Natl Acad Sci U S A. 2020; 117(4): 2187–2193. PMID: 31932420.Since their discovery ~70 years ago, glucocorticoids (GC) have been widely used to elicit a systemic anti-inflammatory response, and currently play a major role in the treatment of asthma and other inflammatory diseases (1). However, unresponsiveness to GC in some individuals i...