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ey0020.2-12 | New Perspectives | ESPEYB20

2.12. Pappalysins and stanniocalcins and their relationship with the peripheral IGF axis in newborns and during development

A Martin-Rivada , S Guerra-Cantera , A Campillo-Calatayud , EM Andres-Esteban , M Sanchez Holgado , GA Martos-Moreno , J Pozo , M Guemes , L Soriano-Guillen , A Pellicer , C Oxvig , J Frystyk , JA Chowen , V Barrios , J Argente

Brief summary: Growth Hormone (GH)-Insulin-Growth-Factor-1 (IGF-1) axis plays the major role in promoting growth, but novel factors seem to modulate GH-IGF1 axis functioning. The majority of circulating IGF-1 and IGF-2 are bound to IGF-binding proteins (IGF-BPs) which prolong their half-life and regulate their tissue distribution (1,2). Pappalysins (PAPP-A, PAPP-A2) increase IGF-1 bioavailability through cleavage of IGFBPs and are inhibited by stanniocalcins (STC1, STC2) (3,4)...

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ESPE Yearbook of Paediatric Endocrinology

2.12. Pappalysins and stanniocalcins and their relationship with the peripheral IGF axis in newborns and during development

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